Skip Navigation

HazMap: Occupational Exposure to Hazardous Agents
HazMap Home SIS Home NLM Home

as Search Agents Search Diseases Search Jobs Full Text Search


Haz-Map Home on-tab Custom Search on-tab Help on-tab Web Glossary on-tab Reference on-tab
left corner Browse Haz-Map
right corner
Agent Name Nitrogen chloride
Alternative Name Nitrogen trichloride
CAS Number 10025-85-1
Formula Cl3-N
Major Category Nitrogen Compounds
Synonyms Agene; Chlorine nitride; Trichloramine; Trichlorine nitride; Nitrogen trichloride; [ChemIDplus]
Category Other Nitrogen Compounds
Sources/Uses A byproduct of water chlorination, it is volatile and strongly irritating; May make the lung more susceptible to allergens; It is formed when organic matter in sweat and urine react with chlorine in swimming pools; [Reference #2]
Comments Occupational asthma in indoor pool workers (lifeguards and a swimming teacher) confirmed by specific bronchoprovocation testing; [Malo] Chloramines include chloramide (NH2Cl), dichloramide (NHCl2), and trichloramide (NCl3). Tricloramide, also called nitrogen chloride or nitrogen trichloride, was the predominant vapor found in the indoor pool environment with a high chlorine to nitrogen ratio. All three swimming pools the study had been treated with sodium hypochlorite. Measured levels of NCl3 ranged from 0.23-0.57 mg/m3 in one pool and 0.1-0.31 in another pool. The concentration used for the challenge tests was 0.5 mg/m3. All 3 workers had immediate asthmatic reactions to the challenge tests, and one had an additional late reaction. [See Reference #1]
Reference Link Occupational asthma caused by chloramines in indoor swimming-pool air
Exposure Assessment
Lethal Concentration LC50 (rat) = 112 ppm/1H
Reference Link The chlorine hypothesis: fact or fiction? [Occup Environ Med. 2007] - PubMed Result
Adverse Effects
Asthma Yes
Links to Other NLM Databases
Toxicity Information Search TOXNET
Chemical Information Search ChemIDplus
Biomedical References Search PubMed
Related Information in Haz-Map
Diseases Occupational diseases associated with exposure to this agent:





Specialized Information Services   U.S. National Library of Medicine,
8600 Rockville Pike, Bethesda, MD 20894
National Institutes of Health
Privacy/Disclaimer Notice
Customer Service: tehip@teh.nlm.nih.gov
Last updated: January, 2009