| Agent Name |
2.4-Dinitrophenol |
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| CAS Number |
51-28-5 |
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| Formula |
C6-H4-N2-O5 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1'alpha-2,4-Dinitrophenol; 1-Hydroxy-2,4-dinitrobenzene; 2,4-Dinitrofenol [Dutch]; 2,4-Dinitrophenol; 2,4-Dnp; AI3-01535; Aldifen; Camello mosquito coils; Chemox PE; Cobra salts; Impregna salts); DNP; Dinitrofenolo [Italian]; Dinofan; EK 102; Fenoxyl carbon N; Maroxol-50; Nitro kleenup; Nitrophen; Nitrophen (VAN); Nitrophene; Nitrophene (VAN); Osmoplastic-R; Osmotox-Plus; Phenol, alpha-dinitro-; P048; Shirakiku brand mosquito coils; Solfo Black 2B Supra; Solfo Black B; Solfo Black BB; Solfo Black G; Solfo Black SB; Tertrosulphur Black PB; Tertrosulphur PBR; X 32; alpha-Dinitrophenol; [ChemIDplus] |
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| Category |
Nitros, Aromatic |
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| Description |
Yellow crystals with a sweet, musty odor; [CHRIS] |
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| Sources/Uses |
Used as a chemical intermediate (dyes and photographic developers), biocide in metal-working fluids, wood preservative, insecticide, polymerization inhibitor (styrene production), and veterinarian medication; [HSDB] |
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| Comments |
In the 1930s, it was used to treat obesity. Reported adverse effects included agranulocytosis, neuritis, and heart damage. Poisoning by ingestion causes uncoupling of oxidative phosphorylation with high fever, sweating, tachycardia, abdominal pain, anxiety, rapid breathing that may end in convulsions and death. Poisoning has also caused toxic hepatitis, renal failure, and cataract formation. [HSDB] May cause first degree burns after short exposure and second degee burns after longer contact; May cause cataracts after chronic exposure; [CHRIS] There is a case report of dinitrophenol causing cholestatic jaundice. [Zimmerman, p. 351] See "Dinitrophenol." |
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| Restricted |
Its use as a pesticide was cancelled. [HSDB] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Not evaluated |
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| Vapor Pressure |
0.00039 mm Hg |
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| Lethal Concentration |
LCLo (dog) = 300 mg/m3/30 min |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Dermatotoxin |
Skin Burns |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Nephrotoxin |
Yes |
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| Other Poison |
Uncoupler |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 2,4-DINITROPHENOL
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