| Agent Name |
Methyl cellosolve acetate |
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| Alternative Name |
2-Methoxyethyl acetate |
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| CAS Number |
110-49-6 |
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| Formula |
C5-H10-O3 |
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| Major Category |
Solvents |
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| Synonyms |
2-Methoxy-ethyl acetaat [Dutch]; 2-Methoxyaethylacetat [German]; 2-Methoxyethanol, acetate; 2-Methoxyethyl acetate; 2-Methoxyethyle, acetate de [French]; 2-Methoxyethylester kyseliny octove [Czech]; 2-Methyoxyethylacetate; 2-Metossietilacetato [Italian];Acetate de l'ether monomethylique de l'ethylene-glycol; [French]; Acetate de methyle glycol [French]; Acetato di metil cellosolve [Italian]; Acetic acid 2-methoxyethyl ester; Acetyl methyl cellosolve; Aethylenglykolmethylaetheracetat [German]; EGMEA; Ethanol, 2-methoxy-, acetate; Ethylene glycol acetate monomethyl ether; Ethylene glycol methyl ether acetate; Ethylene glycol monomethyl ether acetate; Ethylene glycol monomethyl ether monoacetate; Glycol monomethyl ether acetate; MeCsac; Methyl Cellosolve acetate; Methyl cellosolye acetaat [Dutch]; Methyl glycol acetate; Methyl glycol monoacetate; Methylcellosolveacetate; Methylcelosolvacetat [Czech]; Methylglycolacetate; Methylglykolacetat [German]; beta-Methoxyethyl acetate; [ChemIDplus] UN1189 |
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| Category |
Glycol Ethers |
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| Description |
Colorless liquid with a pleasant odor; [CAMEO] |
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| Sources/Uses |
Used as a solvent and in the production of photographic films and textile printing; [ACGIH] |
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| Comments |
After repeated 8-hour exposures to 200-1000 ppm, animals show evidence of kidney and bone marrow damage. [ACGIH] For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] Potential adverse effects include injury to the bone marrow, kidneys, and CNS (unconsciousness). May be a reproductive toxin and defat the skin; [ICSC] See "Glycol ethers." |
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| Exposure Assessment |
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| BEI |
2-Methoxyacetic acid in urine--screen for mg/g creatinine; end of shift at end of workweek; |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
0.1 ppm |
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| PEL (OSHA) |
25 ppm |
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| MAK |
5 ppm |
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| IDLH (NIOSH) |
200 ppm |
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| Excerpts from Documentation for IDLHs |
Human data: It has been stated that methyl Cellosolve� acetate is slightly less toxic than methyl Cellosolve� [Gosselin et al. 1984] |
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| Vapor Pressure |
2 mm Hg |
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| Odor Threshold Low |
0.33 ppm |
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| Odor Threshold High |
0.64 ppm |
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| Lethal Concentration |
LCLo (rats) = 7,000 ppm/4 hr |
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| Explanatory Notes |
Detection odor threshold from AIHA (mean = 0.33 ppm); Flash point = 111 deg F; |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Nephrotoxin |
Yes |
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| Reproductive Toxin |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: METHYL CELLOSOLVE ACETATE
|
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