Agent Name |
2-Chloroaniline |
Alternative Name |
o-Chloroaniline |
CAS Number |
95-51-2 |
Formula |
C6-H6-Cl-N |
Major Category |
Nitrogen Compounds |
Synonyms |
1-Amino-2-chlorobenzene; 2-Chloroaniline; 2-Chlorobenzenamine; 2-Chlorophenylamine; Aniline, o-chloro-; Benzenamine, 2-chloro-; Fast Yellow GC Base; o-Aminochlorobenzene; o-Chloraniline; o-Chloroaminobenzene; o-Chloroaniline; [ChemIDplus] UN2019 |
Category |
Amines, Aromatic |
Description |
Clear amber liquid with an amine odor; [CAMEO] |
Sources/Uses |
Used as an intermediate for dyes, pesticides, and rubber chemicals; [HSDB] |
Comments |
o-Chloroaniline is listed in a table "Examples of Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] "In the United Kingdom between 1961 and 1980, chloroaniline, p-toluidine, nitrobenzene, and nitrochlorobenzene were the most common industrial causes of methemoglobinemia. Dermal exposure was a more frequent route of toxicity than inhalation with these compounds." (Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988.) An eye irritant; Can induce methemoglobinemia; [ICSC] |
Exposure Assessment |
BEI |
Methemoglobin in blood = 1.5% of hemoglobin during or end of shift |
Skin Designation (ACGIH) |
Not evaluated |
Vapor Pressure |
0.2 mm Hg |
Lethal Concentration |
LC50 (rats) = 797 ppm/4h |
Explanatory Notes |
Flash point = 103 deg C; |
Adverse Effects |
Methemoglobinemia |
Methemoglobinemia, Primary |
Links to Other NLM Databases |
Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 2-CHLOROANILINE
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