Protocol Number: 07-M-0129

Title:

PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using (11C)PBR28 in HIV-Seropositive Patients with (MCMD)

Number:

07-M-0129

Summary:

The purpose of this protocol is to measure a receptor in the brain using positron emission tomography (PET) that is involved in inflammation.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Recruitment has not started

Gender: Male & Female

Referral Letter Required: Yes

Population Exclusion(s): Children

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Special Instructions:

Currently Not Provided

Keyword(s):

HIV-Dementia

Brain

PET

PBR28

MCMD

Recruitment Keyword(s):

HIV Positive

HIV Dementia

AIDS Related Dementia

Minor Cognitive Motor Disorder

MCMD

Healthy Volunteer

HV

Condition(s):

HIV-Dementia

HIV-Associated Cognitive Motor Complex

AIDS Encephalopathy

AIDS Dementia Complex

AIDS-Related Dementia Complex

HIV Infections

Healthy

Investigational Drug(s):

None

Investigational Device(s):

None

Interventions:

Drug: [11C]PBR28

Supporting Site:

National Institute of Mental Health

Contact(s):

This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):

Anderson E, Zink W, Xiong H, Gendelman HE. HIV-1-associated dementia: a metabolic encephalopathy perpetrated by virus-infected and immune-competent mononuclear phagocytes. J Acquir Immune Defic Syndr. 2002 Oct 1;31 Suppl 2:S43-54.

Anholt RR, De Souza EB, Oster-Granite ML, Snyder SH. Peripheral-type benzodiazepine receptors: autoradiographic localization in whole-body sections of neonatal rats. J Pharmacol Exp Ther. 1985 May;233(2):517-26.

Amodio P, Wenin H, Del Piccolo F, Mapelli D, Montagnese S, Pellegrini A, Musto C, Gatta A, Umilta C. Variability of trail making test, symbol digit test and line trait test in normal people. A normative study taking into account age-dependent decline and sociobiological variables. Aging Clin Exp Res. 2002 Apr;14(2):117-31.

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department Clinical Research Informatics, CC.

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