Protocol Number: 07-C-0138

Title:

A Phase II Trial of GW786034 (Pazopanib) in Subjects with Recurrent Glioblastoma

Number:

07-C-0138

Summary:

Background:

Glioblastoma multiforme is a type of brain tumor whose growth is highly dependent on new blood vessels that grow in the tumor to nourish and support it.

An experimental drug called GW786034 is believed to interfere with the formation of new blood vessels in tumors.

Objectives:

To determine whether GW786034 can slow tumor growth in patients with glioblastoma.

To determine the safety profile of GW786034 in the treatment of malignant glioma patients.

To characterize the pattern of changes of specific proteins associated with new blood vessel growth over time across patients.

Eligibility:

Patients 18 years of age and older with a glioblastoma who no longer benefit from standard treatment.

Design:

Patients take 800 mg of GW786034 a day by mouth in uninterrupted 28-day treatment cycles.

Patients have the following procedures at specified intervals during treatment:

-Physical examinations, including neurocognitive tests to determine the effect of the brain tumor on everyday living.

-MRI scans of the head (imaging test using a magnetic field and radio waves)

-PET scans of the head (imaging test using radioactive tracers)

-Blood tests

-Blood pressure monitoring twice a day at home.

-Completion of a pill diary and a blood pressure diary.

-Follow-up visits with the doctor

Sponsoring Institute:

National Cancer Institute (NCI)

Recruitment Detail

Type: No longer recruiting/follow-up only

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Special Instructions:

Currently Not Provided

Keyword(s):

Chemotherapy

Brain Tumor

Recurrence

Radiotherapy

Progression

Recruitment Keyword(s):

Glioblastoma Multiforme

GBM

Brain Tumor

Condition(s):

Glioblastoma Multiforme

Investigational Drug(s):

Pazopanib, GW786034

Investigational Device(s):

None

Interventions:

Drug: GW786034

Drug: Pazopanib, GW786034

:

Supporting Site:

National Cancer Institute

Contact(s):

This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):

Moss AR. Occupational exposure and brain tumors J Toxicol Environ Health. 1985;16(5):703-11

Bovet P, Lob M. [Cancer mortality among the workers of a Swiss rubber goods factory. Epidemiological study, 1955-75] Schweiz Med Wochenschr. 1980 Aug 30;110(35):1277-8

Copeland DD, Bigner DD. Glial-mesenchymal tropism of in vivo avian sarcoma virus neuro-oncogenesis in rats. Acta Neuropathol (Berl). 1978 Jan 19;41(1):23-5

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
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