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Protocol Number:
97-C-0093
- Title:
A Pilot Study of 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Pediatric Patients with Primary and Metastatic Brain Tumors
- Number:
97-C-0093
- Summary:
Brain tumors represent the most common solid tumor of childhood. Treatment generally entails surgery and radiation, but local recurrence is frequent. Chemotherapy is often used in an adjuvant setting, to delay radiation therapy or for resistant disease. Children with brain tumors are generally followed by imaging studies, such as CT or MRI. Difficulty arises in trying to distinguish tumor regrowth from treatment related edema, necrosis or radiation injury. Proton Nuclear Magnetic Resonance Spectroscopic (NMRS) Imaging is a non-invasive method of detecting and measuring cellular metabolites in vivo. NMRS imaging complements routine MRI by giving chemical information in conjunction with spatial information obtained by MRI.
This study will be conducted to determine NMRS imaging patterns before, during and after chemotherapy in pediatric patients with primary or metastatic brain tumors in an attempt to identify and characterize specific patterns of metabolites related to tumor regrowth, tumor response to therapy, edema or necrosis.
- Sponsoring Institute:
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National Cancer Institute (NCI)
- Recruitment Detail
- Type:
Completed Study; data analyses ongoing
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Special Instructions:
Currently Not Provided
- Keyword(s):
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Non-Invasive
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Children
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Metabolites
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Multivoxel
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Multislice
- Recruitment Keyword(s):
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None
- Condition(s):
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Brain Neoplasm
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Neoplasm Metastasis
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Interventions:
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Procedure/Surgery: Nuclear Magnetic Resonance Spectroscopic (NMRS) Imaging
- Supporting Site:
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National Cancer Institute
- Contact(s):
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This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Citation(s):
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Clinical applications of proton MR spectroscopy
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Proton magnetic resonance spectroscopy of pediatric brain tumors
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Multislice proton spectroscopic imaging of the human brian
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/30/2009
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