Protocol Number: 95-H-0167

Title:

Effect of Hypoxia and Smoking on Oxidation of Proteins and Nucleic Acids in Human Volunteers

Number:

95-H-0167

Summary:

Patients with lung disease experiencing difficulty breathing can be treated with oxygen therapy. This involves the delivery of "extra" oxygen by a face-mask or through small tubes placed in the nose called nasal prongs. This extra oxygen can have concentrations as high as 100% pure oxygen. The concentration of oxygen in normal air is only 21%. The high concentration of oxygen can help to provide enough oxygen for all of the organs in the body. Unfortunately, breathing 100% oxygen for long periods of time can cause changes in the lungs, which are potentially harmful. Researchers believe that by lowering the concentration of oxygen therapy to 40% patients can receive it for longer periods of time without the risk of side effects.

This study is designed to evaluate the effects of oxygen therapy at 100% and 40% for 12 - 18 hours on the lungs of normal volunteers. Results of this study will help to determine if levels of oxygen therapy currently accepted as being "safe" may actually be damaging to the lungs.

Sponsoring Institute:

National Heart, Lung and Blood Institute (NHLBI)

Recruitment Detail

Type: Completed Study; data analyses ongoing

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Special Instructions:

This protocol includes 3 bronchoscopies. I t includes 3 visits 2 weeks apart. The 2nd visit involves oxygen by mask for 14-18 hours.

Keyword(s):

Oxygen

Bronchoalveolar Lavage

DNA Repair

Carbonyl Groups

Serum

ADP-ribosylation

Defensin

Protein Oxidation

Recruitment Keyword(s):

Human Volunteers

Condition(s):

Healthy

Hyperoxia

Investigational Drug(s):

None

Investigational Device(s):

None

Interventions:

Procedure/Surgery: Oxygen therapy

Supporting Site:

National Heart, Lung and Blood Institute

Contact(s):

This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):

Normobaric oxygen toxicity of the lung

In vivo antioxidant gene expression in human airway epithelium of normal individuals exposed to 100% O(2)

Pulmonary oxygen toxicity Early reversible changes in human alveolar structures induced by hyperoxia

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department Clinical Research Informatics, CC.

Search The Studies | Help | Questions |
Clinical Center Home | NIH Home

National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/30/2009