|
Protocol Number:
08-M-0049
- Title:
Imaging of Cannabinoid CB1 Receptors Using [18F]MePPEP-d2
- Number:
08-M-0049
- Summary:
The purpose of this protocol is to measure brain CB1 receptors in the hope to better understand how they work, so that one day we can understand how the CB1 receptors are involved in psychiatric, neurological, and behavioral disorders.
- Sponsoring Institute:
-
National Institute of Mental Health (NIMH)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA:
-All subjects must be healthy and aged 18-65 years, with history/physical exam, ECG, and laboratory tests within one year of the PET scan.
-The volunteer must sign an informed consent form.
EXCLUSION CRITERIA:
-Current psychiatric illness, substance abuse including marijuana use, or severe systemic disease based on history and physical exam.
-Laboratory tests with clinically significant abnormalities or positive urine toxicology screen.
-Prior participation in other research protocols in the last year such that radiation exposure would exceed the annual limits.
-Pregnancy and breast feeding.
-Claustrophobia.
-Presence of ferromagnetic metal in the body or heart pacemaker.
-Positive HIV test.
-Employee of the investigative site or an immediate family member of an employee of the investigative site. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.
-Employee of Eli Lilly and Company.
- Special Instructions:
Currently Not Provided
- Keywords:
-
CB1 Receptor
-
PET
-
Cannabinoid
-
[18F]FMPEP-d2
-
Brain Imaging
- Recruitment Keyword(s):
-
Healthy Volunteer
-
HV
- Condition(s):
-
CB1
-
Cannabinoid
-
PET
-
[18F]FMPEP-d2
-
Brain Imaging
- Investigational Drug(s):
-
[18F]FMPEP-d2
- Investigational Device(s):
- None
- Intervention(s):
-
Drug: [18F]FMPEP-d2
- Supporting Site:
- National Institute of Mental Health
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
-
Abi-Dargham A, Gandelman M, Zoghbi SS, Laruelle M, Baldwin RM, Randall P, Zea-Ponce Y, Charney DS, Hoffer PB, Innis RB. Reproducibility of SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil. J Nucl Med. 1995 Feb;36(2):167-75.
-
Burger C, Buck A. Requirements and implementation of a flexible kinetic modeling tool. J Nucl Med. 1997 Nov;3 (11):1818-23.
-
Burns HD, Van Laere K, Sanabria-Boh—rquez S, Hamill TG, Bormans G, Eng WS, Gibson R, Ryan C, Connolly B, Patel S, Krause S, Vanko A, Van Hecken A, Dupont P, De Lepeleire I, Rothenberg P, Stoch SA, Cote J, Hagmann WK, Jewell JP, Lin LS, Liu P, Goulet MT, Gottesdiener K, Wagner JA, de Hoon J, Mortelmans L, Fong TM, Hargreaves RJ. [18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9800-5. Epub 2007 May 29.
If you have:
Search The Studies | Help | Questions | Clinical Center Home | NIH Home
National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/30/2009
|
|