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Protocol Number:
08-I-0034
- Title:
Validation of (1)H-Magnetic Resonance Spectroscopy for Quantification of Hepatic Triglyceride Content
- Number:
08-I-0034
- Summary:
This study will determine whether a magnetic resonance imaging (MRI) test of the liver can accurately measure the amount of fat in the liver compared to the results of a liver biopsy.
People 18 years of age and older who are scheduled to have or who have already had a liver biopsy as part of their medical care within 1 month of enrollment in this study may be eligible to participate.
Participants undergo an MRI. For this procedure, the subject lies still on a table that slides into a narrow metal cylinder (the MRI scanner) for 30 to 60 minutes. A special pad or tube is placed around the abdomen to improve the image of the liver obtained. Earplugs are placed in the ears to muffle loud thumping and knocking sounds that occur with the electrical switching of the magnetic field. The findings of the MRI are compared with those of the liver biopsy.
- Sponsoring Institute:
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National Institute of Allergy and Infectious Diseases (NIAID)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA:
Age 18+, male or female
Planned liver biopsy or liver biopsy within the past month with pathology samples available to be read at NIH CC
EXCLUSION CRITERIA:
Known current pregnancy or pregnancy within 6 months
Contraindications to MRI
Subject is deemed unable to comply with requirements of study participation
- Special Instructions:
Currently Not Provided
- Keywords:
-
1H-Magnetic Resonance Spectroscopy
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Hepatic Steatosis
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Liver Fat
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Liver Biopsy
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Liver
- Recruitment Keyword(s):
-
Hepatitis
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Fatty Liver
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Liver Biopsy
- Condition(s):
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Fatty Liver
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Hepatitis
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
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Procedure/Surgery: Diagnostic Radiology: 1H-MRS of the liver
- Supporting Site:
- National Institute of Allergy and Infectious Diseases
- Contact(s):
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Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Nakao K, Nakata K, Ohtsubo N, Maeda M, Moriuchi T, Ichikawa T, Hamasaki K, Kato Y, Eguchi K, Yukawa K, Ishii N. Association Between Nonalcoholic Fatty Liver, Markers of Obesity, and Serum Leptin Level in Young Adults. Am J Gastroenterol. 2002 Jul;97(7):1796-801.
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Banerji MA, Buckley MC, Chaiken RL, Gordon D, Lebovitz HE, Kral JG. Liver Fat, Serum Triglycerides and Visceral Adipose Tissue in Insulin-Sensitive and Insulin-Resistant Black Men with NIDDM. Int J Obes Relat Metab Disord. 1995 Dec;19(12):846-50.
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Sabir N, Sermez Y, Kazil S, Zencir M. Correlation of Abdominal Fat Accumulation and Liver Steatosis: Importance of Ultrasonographic and Anthropometric Measurements. Eur J Ultrasound. 2001 Dec;14(2-3):121-8.
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Bethesda, Maryland 20892. Last update: 01/30/2009
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