Protocol Number: 07-M-0082

Title:

PET Imaging of Brain mGluR5 Receptors Using [18F]SP203

Number:

07-M-0082

Summary:

The metabotropic glutamate subtype five (mGluR5) receptor is a protein found in the brain and is the target for the excitatory chemical messenger glutimate. The purpose of this protocol is to measure mGluR5 receptors in the brain using positron emission tomography (PET) and a research drug called [18F]SP203.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: Yes

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA:

Healthy control subjects aged 18-65 years, with history/physical exam, ECG, and laboratory tests within one year of the PET scan within normal limits.

EXCLUSION CRITERIA:

1. Current psychiatric illness, substance abuse or severe systemic disease based on history and physical exam.

2. Laboratory tests with clinically significant abnormalities.

3. Prior participation in other research protocols or clinical care in the last year such that radiation exposure would exceed the annual limits.

4. Pregnancy and breast feeding.

5. Claustrophobia. (part 1 only)

6. Presence of ferromagnetic metal in the body or heart pacemaker. (part 1 only)

7. Positive HIV test.

8. Consumed alcohol within 48 hours before the PET scan.

Special Instructions:

Currently Not Provided

Keywords:

Pharmacokinetics

Binding Potential

Glutamate

Positron Emission Tomography

Metabolic Glutamate Receptors

Recruitment Keyword(s):

Healthy Volunteer

HV

Condition(s):

Healthy

Glutamate Receptor

mGlur5 Protein

Excitatory Amino Acid Receptors

Drug Kinetics

PET Scan

Investigational Drug(s):

[18F]SP203

Investigational Device(s):

None

Intervention(s):

Drug: [18F]SP203

Supporting Site:

National Institute of Mental Health

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Brodkin J, Bradbury M, Busse C, Warren N, Bristow LJ, Varney MA. Reduced stress-induced hyperthermia in mGluR5 knockout mice. Eur J Neurosci. 2002 Dec;16(11):2241-4.

Cosford ND, Roppe J, Tehrani L, Schweiger EJ, Seiders TJ, Chaudary A, Rao S, Varney MA. [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. Bioorg Med Chem Lett. 2003 Feb 10;13(3):351-4.

Fujita M, Seibyl JP, Verhoeff NP, Ichise M, Baldwin RM, Zoghbi SS, Burger C, Staley JK, Rajeevan N, Charney DS, Innis RB. Kinetic and equilibrium analyses of [(123)I]epidepride binding to striatal and extrastriatal dopamine D(2) receptors. Synapse. 1999 Dec 15;34(4):290-304.

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