Protocol Number: 07-DK-0163 ![]()
Healthy pre-menopausal African-American and Caucasian women between 18 and 49 years of age who weigh less than 300 pounds may be eligible for this study. Participants have 10 visits to the NIH Clinical Center to undergo the following procedures: Visit 1 Medical history and physical exam, including questions about the subject's diet, exercise, family, education and employment. Blood tests, urine tests and an electrocardiogram. Visit 2 Brachial artery reactivity study: This test measures the rate at which blood flows through the brachial artery (a blood vessel in the arm). Ultrasound pictures of the arm are taken. Then a blood pressure cuff is placed on the arm and inflated for 5 minutes. After 5 minutes, the cuff is deflated and ultrasound pictures of the arm are taken again. Glucose tolerance test: This test examines how well insulin is controlling the glucose (sugar) and fat in the blood. A catheter (plastic tube) is placed in a vein in each arm. The subject is given glucose through the catheter in one vein. After 20 minutes, a small amount of insulin is given through the same catheter. Blood samples are drawn through the catheter in the other arm at frequent intervals. Visits 3-9 Dietary visits: Subjects come to the Clinical Center for 7 days to be weighed, eat breakfast and take home food for lunch, dinner, and snacks. On one of these seven dietary visits, subjects have the following tests: -CT scan to measure the amount of fat in the abdomen. -DEXA scan to measure total body fat. -Arm, leg, chest and abdomen skinfold thickness measurements. -Waist, thigh and hip measurements. Visits 10 Test Meal: This visit is done to determine how a single meal affects fat levels and vascular function. Height, weight and blood pressure are measured. Then, a catheter is placed in an arm vein and a blood sample is drawn. The brachial artery reactivity study is done as described for Visit 2. Then test meal consisting of a cheddar cheese omelet, orange juice and bagel with cream cheese is eaten. Blood is drawn and the brachial artery study is repeated at 2, 4 and 6 hours after the meal.
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