Protocol Number: 07-CH-0192
Children between 2 and 24 years of age who have been treated for a childhood cancer and have been disease-free for at least 1 year may be eligible for this study. All participants undergo the following procedures: -Review of cancer treatment record -Review of medical and family history -Blood draw for DNA studies -Physical examination and body measurements (height, weight, waist, body proportions) -Completion of child health questionnaires -Individualized screening and counseling program -Review of the following endocrine systems: growth, pituitary and hypothalamic function, thyroid function, ovary and testicular function, bone health, risk of obesity and diabetes The following additional studies may be done, as clinically indicated: -Magnetic resonance imaging (MRI) of the brain -Thyroid, testicular or ovarian ultrasound -DEXA scan to measure bone density -Wrist x-ray to measure bone age -Blood tests -Urine pregnancy test for girls who are old enough to have menstrual periods -Stimulation testing (tests that involve giving medicine by mouth or in the vein and then measuring blood levels of substances afterwards, such as oral glucose tolerance test, arginine-clonidine growth hormone stimulation test, ACTH stimulation test, and gonadotropin-releasing hormone stimulation test) Children with endocrine abnormalities are offered standard treatments.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/30/2009
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