Protocol Number: 06-N-0027

Title:

Neuropsychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure

Number:

06-N-0027

Summary:

This study will explore how the mind and the brain work to cause movement symptoms or seizures in people who do not have a recognized neurological or medical disorder. The study includes a check for psychiatric disorders, symptoms and their severity; psychiatric and personality questionnaires; and neuropsychological testing.

Normal, healthy volunteers, people who have movement symptoms not due to a brain or medical disorder and people who have seizures not due to epilepsy may be eligible for this study. All candidates must be 18 years of age or older.

All participants have a medical history, physical examination and psychological evaluation, including completion of questionnaires. People with movement symptoms or seizures have a symptoms evaluation.

Some participants also undergo neuropsychological testing, including questionnaires, pen-and-paper or computerized tests, and motor tasks.

Sponsoring Institute:

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA:

Patients for dissociation study:

-Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis will be made by a movement disorders neurologist.

-Or a diagnosis of NES based on video-EEG. The diagnosis will be made by an epileptologist.

-Males or females

-Age 18 or older

-Able to provide informed consent

Patients for cognitive study:

-Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis will be made by a movement disorders neurologist.

-Age 18 or older

-Males or females

-Able to provide informed consent

Normal volunteers for cognitive study:

-Normal volunteers age 18 or older will be included

-Males or females

-Able to provide informed consent

EXCLUSION CRITERIA:

Patients for dissociation study:

-Diagnosis of probable or possible PMD using Fahn and Williams criteria.

-Patients with neurological disorders with elaboration of their underlying disease process including comorbid epilepsy.

-Patients with a medical condition that prevents them from taking part in the study.

-Patients with current suicidal ideation.

-Patients with a psychotic disorder.

-Patients with active substance abuse within the last 6 months.

-Patients below the age of 18.

-Patients who are not capable of consent.

-Patients with an IQ less than 55.

-Patients currently involved in lawsuits.

Patients for cognitive study:

-Diagnosis of probable or possible PMD using Fahn and Williams criteria

-Patients with neurological disorders with elaboration of their underlying disease process including comorbid epilepsy

-Patients with a medical condition that prevents them from taking part in the study.

-Patients with a history of a neurological disorder (e.g. dementia, cerebrovascular accident, neurodegenerative disorder, inflammatory disorders or infections of the central nervous system) that may result in cognitive deficits.

-Patients with a history of traumatic brain injury resulting in loss of consciousness or amnesia lasting for more than a few seconds.

-Patients with a psychotic disorder or bipolar disorder

-Patients with a current major depression

-Patients with current moderate to severe anxiety (Hamilton Anxiety Rating Scale greater than 25)

-Patients with current attention deficit hyperactivity disorder.

-Patients with active substance abuse within the last 6 months.

-Patient with current suicidal ideation.

-Patients below the age of 18.

-Patients who are not capable of consent.

-Patients with an IQ less than 55.

-Patients currently involved in lawsuits.

Normal volunteers for cognitive study:

-Normal volunteers younger than 18 years

-Normal volunteers with an active medical condition that might prevent participation.

-Normal volunteers with a history of neurological disorders (e.g. dementia, cerebrovascular accident, neurodegenerative disorder, inflammatory disorders or infections of the central nervous system) that may result in cognitive deficits

-Normal volunteers with a history of traumatic brain injury resulting in loss of consciousness or amnesia lasting for more than a few seconds

-Normal volunteers with a psychotic disorder or bipolar disorder

-Normal volunteers with a current major depression

-Normal volunteers with moderate to severe anxiety (Hamilton Anxiety Rating Scale greater than 25)

-Normal volunteers with active substance abuse within the last 6 months

-Normal volunteers with current attention deficit hyperactivity disorder

-Normal volunteers with an IQ less than 55

-Normal volunteers who are not capable of consent

Special Instructions:

Currently Not Provided

Keywords:

Conversion Disorder

Somatoform Disorder

Involuntary Movement

Childhood Abuse

Depression

Recruitment Keyword(s):

Psychogenic Movement Disorder

PMD

Non-Epileptic Seizure

NES

Healthy Volunteer

HV

Condition(s):

Psychogenic movement disorders

Non-epileptic seizures

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

None

Supporting Site:

National Institute of Neurological Disorders and Stroke

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Williams DT, Ford B, Fahn S. Phenomenology andpsychopathology related to psychogenic movement disorders. Adv Neurol. 1995;65:231-57. Review. No abstract available.

Carson AJ, Ringbauer B, Stone J, McKenzie L, Warlow C, Sharpe M. Do medically unexplained symptoms matter? A prospective cohort study of 300 new referrals to neurology outpatient clinics. J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):207-10.

Stone J, Carson A, Sharpe M. Functional symptoms and signs inneurology: assessment and diagnosis. J Neurol Neurosurg Psychiatry. 2005 Mar;76 Suppl 1:i2-12. Review. No abstract available.

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Clinical Research Informatics, CC.

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