Protocol Number: 06-I-0106
People 18 years of age and older with severe influenza infection requiring hospitalization or with avian influenza infections may be eligible for this study. Candidates are screened with a nasal swab, throat swab and nasal wash to look for virus. For the nasal wash, a small amount of salt water is squirted in the nose and removed by suction. Participants are randomly assigned to receive either the standard dose or higher dose of Tamiflu. They take the medication twice a day for 5 days. Patients who are still very ill at 5 days and meet certain conditions are given the medicine for another 5 days. Patients are admitted to the hospital, in isolation, for the duration of treatment. In addition to treatment, patients have the following tests and procedures: -Nose and throat swabs, nasal wash, rectal swab, blood and urine tests and chest x-ray before starting treatment -Blood draws on study days 1, 3, 5 and 7 -Nose and throat swabs every day for the first 5 days and on days 10, 14 and 28 -Rectal swabs days every day for the first 5 days and on days 10, 14 and 28 Patients with bird flu are seen in the clinic at 2 and 6 months. A repeat blood test is done at 6 months.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/30/2009
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