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Protocol Number:
00-DK-0221
- Title:
Evaluation of the Immune Response in Humans After Exposure to Hepatitis C Virus
- Number:
00-DK-0221
- Summary:
This study will identify and characterize immune factors involved in hepatitis C infection and elimination of the virus. Individual responses to hepatitis C infection vary; some people are able to eliminate the virus, whereas others remain chronically infected. This study may identify factors important in preventing infection that may be of help in developing a vaccine or more effective treatments.
People over 18 years old who have been exposed to hepatitis C virus may participate in this study. Subjects will be recruited from the National Institutes of Health, Inova Fairfax Hospital, Occupational Medical Services-IDP P.C., Washington Hospital Center and Holy Cross Hospital, all in the Washington, D.C. metropolitan area. Individual patients from other centers will also be recruited on a case by case basis.
Participants will have 40 to 60 cc (1 to 2 ounces) of blood drawn at seven intervals. The first collection will be as soon as possible after exposure to hepatitis C virus and then again at 2, 4, 6, 12, 24, and 48 weeks after exposure. The white blood cells will be studied for their response to the virus, and markers for infection will be followed. If infection develops, additional samples of blood may be requested, and patients will be offered evaluation for treatment. Test results will be kept confidential and will not be entered into any medical records.
- Sponsoring Institute:
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA:
Male or female;
All ethnic groups;
Age above 18 years;
Defined exposure to hepatitis C.
EXCLUSION CRITERIA:
Subjects with a Hct of less than 30.
- Special Instructions:
Currently Not Provided
- Keywords:
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Hepatitis C
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Exposure
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Immune Response
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Cytokines
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Viral Sequence
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PCR
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T Cell
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Seroconversion
- Recruitment Keyword(s):
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None
- Condition(s):
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Hepatitis C
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Institute of Diabetes and Digestive and Kidney Diseases
- Contact(s):
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Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Risk of hepatitis C seroconversion after occupational exposures in health care workers
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A prospective study of hepatitis C virus infection after needlestick accidents
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Study of needlestick accidents and hepatitis C virus infection in healthcare workers by molecular evolutionary analysis
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/30/2009
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