Protocol Number: 99-M-0172

Title:

Integrating EEG/MEG and fMRI: Activity Correlation between Frontal and Temporal Lobe Structures in Schizophrenic Patients, Their Siblings and Unrelated Normal Volunteers

Number:

99-M-0172

Summary:

This study will explore how the brain works during memory testing in an effort to understand why some patients with schizophrenia have memory difficulties.

Patients with schizophrenia and their unaffected family members are eligible for this study. Studying family members may help identify the genes related to the memory deficit in schizophrenia. Normal volunteers will also be studied.

Normal volunteers, patients with schizophrenia, and their family members interested in participating in this study will be screened with a complete medical examination and psychiatric assessment, and performance of simple tasks. Study participants will be shown numbers on a screen and asked to recall them after a brief period. This will be done during electroencephalographic (EEG) recording, in which electrodes attached to the scalp measure the brain's electrical activity. The same test will be repeated while the patient has magnetic resonance imaging of the brain. The combined MRI and EEG testing will permit better localization of the brain's electrical activity.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA:

Controls:

1) No psychiatric or severe chronic medical illness at the time of the study, and by history. This includes the absence of substance abuse histories, learning disabilities and all DSM IV disorders. The investigators will evaluate medical histories and medical conditions that are judged not to interfere with the study may be allowed.

2) No use of psychotropic substances in the last 3 months.

3) There is no upper age limit the lower age limit is 18 years.

Patients:

1) Schizophrenia, any subtype or schizoaffective disorder according to DSM IV, as detailed in protocol # 89-M-0160 ("Inpatient evaluation of neuropsychiatric inpatients", Dr. Jose Apud, principal investigator) and # 95-M-0150 ("A Longitudinal Investigation of Siblings of Schizophrenic and Manic-Depressive Patients", Dr. Daniel R. Weinberger, principal investigator).

EXCLUSION CRITERIA:

Controls and patients:

1) Impaired hearing.

2) Pregnancy (only for purpose of MRI procedures under separate protocols)

3) Head trauma with loss of consciousness in the last year or any evidence of functional impairment due to and persisting after head trauma. Patients or healthy volunteers with a known risk from exposure to high magnetic fields (e.g. patients with pace makers) and those who have metallic implants (e.g. braces) in the head region (likely to create artifact on the MRI scans) will be excluded from participating in the fMRI studies.

Patients:

1) Coexistence of another major mental illness at the time of the study. If the patients experienced other mental illnesses in the past (e.g. a learning disability or major depression), then this should be judged to be fully recovered.

2) Criteria for substance abuse met in the last 6 months.

3) Criteria for substance dependence met in the last year. If criteria for dependence were met in the past, then the duration of the disorder was less than 3 years, or not judged to have produced long-term brain changes to allow the patient to be in the study.

4) Major concurrent medical illness likely to interfere with the acquisition of the task.

5) Concomitant medications which could interfere with performance on the task.

6) Presence of dyskinetic movements of the face and tongue (likely to interfere with eyeblink measures), or of gross involuntary movements of the whole body (likely to interfere with positioning in the MRI scanner).

Special Instructions:

Currently Not Provided

Keywords:

Functional Connectivity

Frontotemporal Interaction

Electrophysiology

Functional Magnetic Resonance Imaging

Healthy Subjects

Schizophrenia

MEG

Neuroimaging

EEG

MRI

Recruitment Keyword(s):

Schizophrenia

Condition(s):

Healthy

Schizophrenia

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

None

Supporting Site:

National Institute of Mental Health

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Relationship between electrical potentials of the hippocampus, amygdala and neocortex during instrumental conditioning reflexes

Combined dynamics of EEG and evoked potentials I studies of simultaneously recorded EEG-EPograms in the auditory pathway, reticular formation and hippocampus of the cat brain during the walking stage

P300-response: possible psychophysiological correlates in delta and theta frequency channels

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National Institutes of Health Clinical Center Bethesda, Maryland 20892. Last update: 01/30/2009