NIH Clinical Research Studies

Protocol Number: 94-D-0018

Active Accrual, Protocols Recruiting New Patients

Title:
Salivary Evaluation in Normal Volunteers
Number:
94-D-0018
Summary:
The purpose of this study is to collect information about normal salivary function for comparison with that of patients with salivary gland dysfunction.

Healthy normal volunteers between 20 and 70 years of age may be eligible for this study. People who have significant health problems or who are taking any medications other than birth control pills or who have a dry mouth problem may not enroll in this study.

Participants will have the following procedures:

- Medical and dental history

- Blood sample collection

- Urine sample collection

- Saliva collection - Saliva samples are collected from the parotid and submandibular/sublingual glands-the major saliva-producing glands located in the cheeks and under the jaw-using small suction devices.

- Salivary gland biopsy - A biopsy (removal of small tissue sample) of the minor salivary glands in the lower lip will be done to obtain tissue for experimentation. After the biopsy site (the inner surface of the lip) is numbed with an anesthetic, an incision is made and several tiny salivary glands are removed. The wound is then closed with stitches, which will be removed at a follow-up visit

Sponsoring Institute:
National Institute of Dental And Craniofacial Research (NIDCR)
Recruitment Detail
Type: Participants currently recruited/enrolled
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): Children

Eligibility Criteria:
INCLUSION CRITERIA:

-Participants in Normal Volunteer program

-No medications, with the exception of oral contraceptives or hormone replacement therapy.

-Good general health

EXCLUSION CRITERIA:

-Medical Illness

-Blood-borne disease

-Sicca symptoms

Special Instructions:
Currently Not Provided
Keywords:
Saliva
Parotid
Lip Biopsy
Health
Exocrine
Recruitment Keyword(s):
Normal Volunteer
Condition(s):
Healthy
Salivary Gland Disease
Investigational Drug(s):
None
Investigational Device(s):
None
Intervention(s):
None
Supporting Site:
National Institute of Dental and Craniofacial Research

Contact(s):
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s): Not Provided

Active Accrual, Protocols Recruiting New Patients

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