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Protocol Number:
91-CH-0127
- Title:
Ovarian Follicle Function in Patients with Premature Ovarian Failure
- Number:
91-CH-0127
- Summary:
Premature ovarian failure may be the result of the destruction of eggs in the ovaries. Some patients experience complete destruction of all eggs within the ovaries. In these cases, no treatment will restore egg development.
However, some patients experience a condition known as premature autoimmune ovarian failure. In these cases eggs still remain in the ovaries, but they are prevented from working normally by the body's own immune system.
This study was designed to evaluate patients with premature ovarian failure. It will provide researchers with information that may be used later in other studies related to this condition. In addition, patients participating in this study may be selected for other studies that may benefit them directly.
- Sponsoring Institute:
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National Institute of Child Health and Human Development (NICHD)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Female
- Referral Letter Required:
Yes
- Population Exclusion(s):
Male
Children
- Eligibility Criteria:
INCLUSION CRITERIA:
Women 18 to 42 years of age with premature ovarian failure who meet the following requirements will be candidates for the study: 1) at least a four month history of amenorrhea not due to pregnancy, and 2) at least two documented serum FSH levels or two documented LH levels in the menopausal range for the corresponding assay (greater than or equal to 20 U/ml for FSH and greater than or equal to15 U/L for LH in the current Clinical Center assays).
EXCLUSION CRITERIA:
Women with evidence for karyotypic, metabolic, toxic, or iatrogenic cause of the ovarian failure will not be candidates.
- Special Instructions:
Currently Not Provided
- Keywords:
-
Menopause
-
Estrogen
-
Infertility
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Ovulation
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Amenorrhea
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Hypergonadotropic Hypogonadism
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Young Women
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Gonadal Steroid Deficiency
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Mineralocorticoid Deficiency
- Recruitment Keyword(s):
-
Premature Ovarian Failure
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POF
- Condition(s):
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Amenorrhea
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Hypoaldosteronism
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Hypogonadism
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Infertility
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Premature Ovarian Failure
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Institute of Child Health and Human Development
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Development of luteinized Graafian follicles in patients with karyotypically normal spontaneous premature ovarian failure
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The use of human recombinant gonadotropin receptors to search for IgG mediated premature ovarian failure
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Routine endocrine screening for patients with karyotypically normal spontaneous premature ovarian failure
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/30/2009
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