Protocol Number: 89-M-0006

Title:

Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Controls

Number:

89-M-0006

Summary:

Magnetic Resonance Imaging (MRI) unlike X-rays and CT-scans does not use radiation to create a picture. MRI use as the name implies, magnetism to create pictures with excellent anatomical resolution. Functional MRIs are diagnostic tests that allow doctors to not only view anatomy, but physiology and function. It is for these reasons that MRIs are excellent methods for studying the brain.

In this study, researchers will use MRIs to assess brain anatomy and function in normal volunteers and patients with a variety of childhood onset psychiatric disorders. The disorders include attention deficit disorder, autism, congenital adrenal hyperplasia, childhood-onset schizophrenia, dyslexia, multidimensional impairment syndrome, obsessive compulsive disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection (PANDAS), stuttering, Sydenham's chorea, and Tourette's syndrome.

Results of the MRIs showing the anatomy of the brain and brain function will be compared across age, sex (gender), and diagnostic groups. Correlations between brain and behavioral measures will be examined for normal and clinical populations.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Clinical populations are included based on DSM-IV criteria.

Inclusion Requirements - Normal Volunteers

Healthy subjects consenting to participation in the study.

EXCLUSION CRITERIA:

Exclusions - Normal Volunteers

Presence of any psychiatric disorders on structured psychiatric interview (DICA-IV).

Current or past use of psychiatric medication.

Special service needs in school.

Presence of known genetic conditions.

If under the age of 18, parent and teacher ratings greater than one SD of population means on ADHD/hyperactivity factors.

Presence or history of medical conditions known to affect cerebral anatomy.

Head injury with loss of consciousness.

Braces.

Metal implants or other contraindications for MRI scanning.

Presence of metal objects, pregnancy, or inability to provide a specimen to rule out pregnancy in females over age 12.

Special Instructions:

This is not a treatment protocol.

Keywords:

Autism

Dyslexia

Magnetic Resonance Imaging

Attention Deficit Hyperactivity Disorder

Twin

Childhood Onset Schizophrenia

Obsessive Compulsive Disorder

Sydenham's Chorea

Tourette's Disorder

Klinefelter's Syndrome

Recruitment Keyword(s):

Congenital Adrenal Hyperplasia

Twin

Condition(s):

Autoimmune Disease

Congenital Adrenal Hyperplasia

Healthy

Mental Disorder Diagnosed in Childhood

Neurologic Manifestations

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

None

Supporting Site:

National Institute of Mental Health

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Quantitative magnetic resonance imaging of human brain development: ages 4-18

Sexual dimorphism of the developing human brain

Quantitative magnetic resonance imaging of the corpus callosum in children and adolescents

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Clinical Research Informatics, CC.

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National Institutes of Health Clinical Center Bethesda, Maryland 20892. Last update: 01/30/2009