INCLUSION CRITERIA - Subject Category A:
Category A will include patients, and relatives, who may or may not be affected who will be evaluated in the Warren G. Magnuson Clinical Center. Patients in this category will be eligible if they or their family members manifest one or more of the following features in a pattern suggestive of a heritable urologic malignant disorder:
-One or more histologically proven or suspected renal carcinomas and/or cysts
-Cerebellar, spinal, medullary or cerebral hemangioblastomas
-Retinal angioma
Pancreatic neuro-endocrine carcinoma, microcystadenoma and/or cysts
-Pheochromocytoma
-Papillary cystadenoma of the epididymis or broad ligament
-Endolymphatic sac tumor
-Known or suspected cutaneous fibrofolliculomas or multiple skin-colored papules
-History of spontaneous pneumothorax
-Lung cysts
-Thyroid carcinoma
-Intestinal polyposis + / - colon cancer
-Cutaneous or Uterine leiomyoma or uterine leiomyosarcoma, sarcoma
INCLUSION CRITERIA - Subject Category B:
Category B will include patients, their at-risk relatives and spouses of patients with inherited urologic malignancies with the above listed clinical findings who live at a distance and who will not be evaluated at the Clinical Center. In some cases, local diagnostic testing may be necessary for these individuals in addition to collection of a blood sample for molecular analysis.
INCLUSION CRITERIA - Subject Category C:
Category C will include relatives and spouses who enroll in this study primarily for genetic linkage studies. These individuals will contribute a blood sample for DNA analysis only. No imaging diagnostic testing will be performed on individuals from this category.
EXCLUSION CRITERIA:
Persons unable to give informed consent.