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Benchmarks for Cancers by Indication for Examination for 714,984 Diagnostic Mammography Examinations from 1996 - 2005

	Work-Up of Abnormal Screening Examination	Short-Interval Follow-Up	Evaluation of Breast Problem/ No Lump or Lump Unknown	Evaluation of Breast Problem/ Palpable Lump	All Diagnostic Examinations
Sensitivity^*	89.5	59.8	75.9	87.8	83.1
Readers with 5+ cancers	213	59	103	202	347
True Positives^†	6,751	709	2,469	5,233	17,532
Cancers^‡	7,540	1,185	3,251	5,962	21,109
Sensitivity (Median-50th percentile)	89.5	62.5	75.3	88.4	82.8
Sensitivity (25th, 75th percentiles)	83.1, 94.7	52.9, 71.9	68.4, 83.3	81.8, 93.2	75, 88.7
Sensitivity (10th, 90th percentiles)	76.2, 100	42.9, 80	58.3, 91.7	71.1, 100	68.6, 92.9
Specificity^§	88.7	96.9	95.7	92.2	93.2
Readers with 100+ non-cancers	314	274	278	231	479
True Negatives^\|\|	149,388	131,249	148,838	78,809	542,775
Non-cancers^#	168,438	135,468	155,597	85,487	582,193
Specificity (Median-50th percentile)	89.2	97.2	96.3	93.2	93.5
Specificity (25th, 75th percentiles)	84.9, 92	95.3, 98.4	93.8, 97.8	89.9, 95.4	90.9, 95.6
Specificity (10th, 90th percentiles)	79.2, 94	92.9, 99	91.3, 98.8	85.9, 97.1	88.1, 97.2

Note: 23,653 (5.2%) examinations were given an initial BI-RADS assessment of zero. The first non-zero assessment within 180 days was used as the final assessment for analysis. Examinations without a non-zero assessment within 180 days were excluded (N=7,943; 1.7%).

^* Sensitivity = the percentage of cancers that had an abnormal interpretation (BI-RADS category 4 or 5).

^† True Positive = the number of cancers that had an abnormal interpretation (BI-RADS category 4 or 5).

^‡ Cancers = the number examinations with a tissue diagnosis of cancer within 1 year following the examination.

^§ Specificity = the percentage of non-cancers that had a negative interpretation (BI-RADS category 1, 2, or 3).

^|| True Negative = the number of non-cancers that had a negative interpretation (BI-RADS category 1, 2, or 3).

^# Non-cancers = the number examinations without a tissue diagnosis of cancer within 1 year following the examination.

The following source must be cited when reproducing this table: NCI-funded Breast Cancer Surveillance Consortium co-operative agreement (U01CA63740, U01CA86076, U01CA86082, U01CA63736, U01CA70013, U01CA69976, U01CA63731, U01CA70040). Downloaded xx/xx/xx from the Breast Cancer Surveillance Consortium Web site - http://breastscreening.cancer.gov/data/benchmarks/diagnostic/table7.html

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