Cre-Drivers for the Mouse Nervous System (web site coming soon) A Blueprint-Funded Resource Fact Sheet:pdfhtml
Supports the design, creation, and characterization of Cre-recombinase-expressing (“Cre-Driver”) mouse lines on the C57B1/6 background, which can be used to drive expression of reporter genes and conditional-ready
alleles in the mouse nervous system.
Through cooperative agreements with three labs, 100 or more novel recombinase-expressing lines will become available in the
next several years along with a recombinase-expression profile for each line.
The principal investigators are Ron Davis at Baylor College of Medicine, Josh Huang at Cold Spring Harbor Laboratory and Uli
Mueller at Scripps Research Institute.
An ongoing contract to map gene expression in the mouse nervous system by generating transgenic mice that carry a bacterial
artificial chromosome (BAC) harboring the gene of interest and an EGFP reporter (principal investigator: Nathaniel Heintz
at the Rockefeller University).
GENSAT also generates BAC Cre-driver lines to serve as tools for cell-specific genetic manipulations in the nervous system (co-principal investigator:
Charles Gerfen at NIMH).
Blueprint funds support the deposition of the transgenic BAC EGFP and BAC Cre-driver lines into MMRRCs.
With primary support from NCRR, these facilities provide central archiving, quality control, and distribution of mouse strains
and mouse embryonic stem cell lines.
Blueprint supplements were awarded to two existing MMRRC sites, the University of California at Davis and the University of
Missouri/Harlan, to facilitate the distribution of mouse lines to the neuroscience community.
Maintains the Mutant Mouse Resource, a repository of mouse models carrying spontaneous genetic mutations; the Induced Mutant Resource, a repository of genetically engineered and induced mutation mouse models; and the Special Mouse Strains Resource, a repository of inbred mouse strain panels for analyzing genetic background effects on mutant genes and complex traits.
All resources are partially supported by the NCRR. .