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Clinical Epilepsy Section
William H. Theodore, M.D., Senior Investigator
Dr. Theodore received his B.A. degree from Harvard College and M.D. degree from Columbia University College of Physicians and Surgeons. After a medical internship and residency, and a neurology residency at Mount Sinai School of Medicine, he came to the National Institutes of Health for a fellowship in Epilepsy and Clinical Neurophysiology. He is board certified in Internal Medicine, Neurology, and Clinical Neurophysiology. In 1988 he became Chief of the Clinical Epilepsy Section, NINDS. He received the American Epilepsy Society Outstanding Clinical Investigator Award in 1991. Dr. Theodore's section is investigating new therapeutic approaches to uncontrolled epilepsy, and using neuroimaging techniques to study cerebral metabolism, neuropharmacology, and functional cognitive anatomy.
Staff:
- Irene Dustin, R.N., Nurse Practitioner, 301-451-9284 dustini@ninds.nih.gov
- Rebecca Fasano, M.D., Research Fellow fasanore@ninds.nih.gov
- William Gaillard, M.D., Volunteer, 301-402-3745 wmdavisg@codon.nih.gov
- Sabina Miranda, M.D., Research Fellow mirandasa@ninds.nig.gov
- Pat Reeves-Tyer, Patient Care Coordinator, 301-496-1923 tyerp@ninds.nih.gov
- Dr. Eva Ritzl, M.D., Volunteer, 301-402-2978 ritzle@ninds.nih.gov
- Susumu Sato, M.D., Senior Investigator, 301-496-5121 Sato@helix.nih.gov
Research Interests:
The Epilepsy Research Branch seeks to improve treatment of epilepsy by understanding the mechanisms of action of antiepileptic drugs, as well as developing new methods for evaluation and treatment. The two sections, Neuronal Excitability and Clinical Epilepsy, collaborate to study the relationship between drug actions at the cellular and subcellular level and clinical effects, both on seizure control and neuropsychological function.
The NINDS Clinical Epilepsy Section (CES) conducts research on the evaluation and treatment of uncontrolled epilepsy, emphasizing non-invasive approaches to localization of epileptic foci and cognitive mapping. The techniques employed include video-EEG monitoring, transcranial magnetic stimulation (TMS), positron emission tomography (PET), and magnetic resonance imaging (MRI), including functional MRI and MR spectroscopy. We use multimodality image co-registration, and statistical parametric mapping, as well as other image analysis techniques. In addition to drug trials, In a double-blind trial, we are exploring the use of transcranial magnetic stimulation, a novel approach to treatment of focal epilepsy.
Current studies include a trial of the therapeutic effect of rTMS on neocortical epileptic foci. We are using PET to study 5HT-1A receptors in localization-related epilepsy, and in patients with both epilepsy and depression. We are using diffusion weighted MRI and BOLD to study the extent of neuronal injury associated with seizures in rats exposed to specific glutamate receptor subtype agonists. In a collaboration with Johns Hopkins University we are investigating the role of the anterior temporal cortex in semantic processing, the amygdala in affective processing, and the effect of white matter pathway resection on cognitive outcome after temporal lobectomy. With Columbia University, we are investigating structural and functional correlates of epilepsy in LGI1 positive kindreds.
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Clinical Protocols:
- Evaluation and Treatment of Patients with Epilepsy 01-N-0139
- Drug-Refractory Neocortical Epilepsy: rTMS Treatment 03-N-0024
- PET Imaging of Serotonin Receptors in Seizure Disorders 99-N-0122
- Cerebral Blood Flow Studies of Language and Memory 91-N-0134
- Quantitative fMRI in Children and Adults Using Arterial Spin Tagging Techniques 02-N-0182
Selected Publications:
- Fotheringham J, Donati D, Akhyani N, Vortmeyer A, Heiss JD, Williams E, Weinstein S, Bruce DA, Gaillard WD, Sato S, Theodore WH, Jacobson S. (2007) Detection of Human Herpesvirus-6B DNA and Antigen in Primary Astrocyte Cultures from Mesial Temporal Lobe Epilepsy Brain Resections., PLoS Med 4(5), e180.
- Theodore WH, Hasler G, Giovacchini G, Kelley K, Reeves-Tyer P, Herscovitch P, Drevets W. (2007) Reduced Hippocampal 5HT1A PET Receptor Binding and Depression in Temporal Lobe Epilepsy., Epilepsia 48, 1526-30.
- Hasler G, Bonwetsch R, Giovacchini G, Toczek MT, Bagic A, Luckenbaugh DA, Drevets WC, Theodore WH. (2007) 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression., Biological Psychiatry 62(11), 1258-64.
- Gaillard WD, Berl MM, Moore EA, Ritzl EK, Rosenberger LR, Weinstein SL, Conry JA, Pearl PL, Ritter FF, Sato S, Vezina LG, Vaidya CJ, Wiggs E, Fratalli C, Risse G, Ratner NB, Giooa G, Theodore WH. (2007) Atypical Language in Lesional and Non-lesional Complex Partial Epilepsy., Neurology 69(18), 1761-71.
- Harden CL, Huff JS, Schwartz T, Zimmerman RD, Weinstein S, Foltin JC, Theodore WH. (2007) Neuroimaging in the emergency patient presenting with seizure, Neurology 69(18), 1772-80.
All Selected Publications
Contact Information:
Dr. William H. Theodore
Clinical Epilepsy Section
Epilepsy Research Branch, NINDS
Building 10, Room 5N250
10 Center Drive, MSC 1408
Bethesda, MD 20892-1408
Telephone: 301-496-1505 office,
301-496-1505 laboratory,
301-402-2871 fax
Email: theodorw@ninds.nih.gov
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