Diabetes: Control - Slide 22

Key points of recent findings:

• Intensive glucose control in newly diagnosed type 1 or type 2 diabetes has benefits during intensive therapy AND a legacy effect for later micro- and macrovascular benefits

• Optimal glucose management should start as early as possible & continue as long as possible

• While the A1C goal for the general population is <7%, treatment must be individualized.

N Engl J Med 2008; 359

Note:

The key points regarding the recent research findings are:

• Intensive glucose control in newly diagnosed people with either type 1 or type 2 diabetes (A1C goal <7%) has benefits during the period of intensive therapy AND a “legacy effect” with micro- and macrovascular benefits realized years later.

• Starting optimal glucose management as early as possible and maintaining it as long as possible in people with either type 1 or type 2 diabetes is beneficial.

• While the A1C goal for the general population is <7%, treatment must be individualized and less stringent control may be appropriate in people with CVD or advanced diabetes complications and in those at risk of severe hypoglycemia.

UKPDS follow up study results reinforce the need for early and optimal blood glucose control and underscore the importance of continual blood pressure management.

Reference

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes N Engl J Med 2008; 359
N Engl J Med 10.1056/NEJMoa0806470

Long-Term Follow-up after Tight Control of Blood Pressure in Type 2 Diabetes N Engl J Med 2008; 359
N Engl J Med 10.1056/NEJMoa0806359

Revised November 2008