Diabetes: Control - Slide 20

UKPDS 10 yr Follow-Up Study-
Blood Pressure findings

• Between group differences lost within 2 yrs

• Significant relative risk reductions in tight control group were not maintained

• Benefits of BP control do not extend beyond intensive therapy period & ongoing treatment is essential

N Engl J Med 2008; 359

Note:

• For blood pressure control, the differences between the tight and standard blood pressure control groups were lost within 2 years after the end of the original study.

• Significant relative risk reductions in tight control group were not maintained over time for any diabetes-related end point, diabetes-related death, microvascular disease, and stroke.

• These finding indicate that benefits of blood pressure control do not extend beyond the period of intensified therapy. Blood pressure control must be continued if benefits are going to be maintained.

Reference

Long-Term Follow-up after Tight Control of Blood Pressure in Type 2 Diabetes N Engl J Med 2008; 359
N Engl J Med 10.1056/NEJMoa0806359

Revised November 2008