Diabetes: Control - Slide 18

UKPDS 10 yr Follow-Up Study-
insulin/sulfonylurea group

• Differences in A1C between intensive & standard glycemic control treatment groups were lost after one year

• Relative risk reductions at 10 yr in intensive insulin/sulfonylurea group:

  • 9% for any diabetes end point (P=0.04)

  • 24% microvascular disease (P=0.001)

  • 15% myocardial infarction (P=0.01)

  • 13% death from any cause (P=0.007)

DPP Research Group. N Engl J Med 2002, Vol.346, No. 6.

Note:

Differences in the A1C values seen in the intensive & standard glycemic control treatment groups were lost one year after of the end of the original study.

“Despite early loss of glycemic differences in the groups, a continued reduction in microvascular risk and emergent risk reductions for MI and death from any cause were observed during 10 years of post-trial follow up.”

Relative risk reductions in intensive insulin/sulfonylurea group:

• 9% for any diabetes-related end point (P=0.04)

• 24% microvascular disease (P=0.001)

• 15% myocardial infarction (P=0.01)

• 13% death from any cause (P=0.007)

Reference

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes N Engl J Med 2008; 359
N Eng J Med 10.1056/NEJMoa0806470