Christopher Columbus is shown landing in the West Indies, on an island that the natives called Guanahani and he named San Salvador, on October 12, 1492. He raises the royal banner, claiming the land for his Spanish patrons, and stands bareheaded, with his hat at his feet, in honor of the sacredness of the event. The captains of the Niña and Pinta follow, carrying the banner of Ferdinand and Isabella. The crew displays a range of emotions, some searching for gold in the sand. Natives watch from behind a tree.

John Vanderlyn (1775-1852) had studied with Gilbert Stuart and was the first American painter to be trained in Paris, where he worked on this canvas for ten years with the help of assistants.