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The National Center for Computational Toxicology (NCCT) is a part of EPA's Office of Research and Development (ORD). Located in Research Triangle Park, North Carolina, NCCT coordinates and implements EPA's research in the field of computational toxicology. NCCT scientists serve as scientific reviewers and advisors by providing technical assistance to other Laboratories and Centers within ORD, to EPA Program Offices and Regions, and to the states. Additionally, NCCT serves as a source of training in computational toxicology by offering seminars, mini-courses, symposia, and staff details.

NCCT is committed to collaborating with other governmental and private organizations to leverage external resources whose complementary expertise can help EPA accelerate progress in high priority research areas. NCCT works closely with the STAR-funded Center for Environmental Bioinformatic Research to provide tools and training to broader scientific audiences and sponsors external research in the field of computational toxicology conducted in support of EPA's mission.

Read more about the science of Computational ToxicologyRead more about the science of Computational Toxicology

bullet image Announcing the First ToxCast Data Analysis Summit

The NCCT is hosting a workshop to explore methods for analyzing the ToxCast data set. Researchers who are interested in accessing the data, analyzing it and presenting results are invited to attend. Read More.

bullet image 48th Annual Meeting of the Society of Toxicology, held March 15–19 at the Baltimore Convention Center, Maryland

The Society of Toxicology (SOT) is a professional and scholarly organization of scientists from academic institutions, government, and industry who practice toxicology in the U.S. and abroad. The Annual Meeting affords the opportunity to learn about the latest scientific achievements from experts in the field of toxicology. View the Web site for links to PDF versions of the many presentations NCCT contributed to the 2009 meeting. Read More

bullet image New and Improved DSSTox Structure Browser for Chemical Analog Searching

The DSSTox Structure Browser v2.0 includes a number of new features to facilitate flexible text (Chemical Name, CAS) and chemical structure searching through 11 published DSSTox Data Files, currently spanning over 6000 chemical structures. New to the Browser are External link-outs based on chemical structure to public resources that include: PubChem, ChemSpider, Lazar In Silico Toxicology, and soon-to-be-activated, ACToR. More Information on DSSTox Structure Browser Update v2.0.

bullet image ToxCast™ Research Program Update

The first phase of ToxCast™ has generated over 10 in vitro datasets, including ~500 assays run on 320 chemicals. These in vitro data are being used to derive predictive signatures for the in vivo toxicities captured in ToxRefDB. The ToxCast™ homepage provides links to datasets, manuscripts, and opportunities for partnering with this exciting research program. Read more

bullet image Computational Toxicology Implementation Plan

Implementation Plan

ORD's Computational Toxicology Research Program Implementation Plan lays out the rationale and short to medium term objectives of the research program in computational toxicology.

The plan discusses the three main components of the program, and details the research issue and relevance, experimental approach, progress to date and milestones over the next three years for each.
Read the Full Implementation Plan (PDF, 100 pp., 930 kb, About PDF)

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