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The chronic fatigue syndrome: a comprehensive approach to its definition and study
Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A, and the International CFS Study Group.The chronic fatigue syndrome: a comprehensive approach to its definition and study.
Annals of Internal Medicine, Vol. 121:pages 953-959, 1994.
This is the most current chronic fatigue syndrome (CFS) research case definition that has been published in the peer reviewed literature. A decision was made to revise the 1988 case definition of CFS because it failed to distinguish cases of CFS from other forms of chronic fatigue. The complexities of the condition and its inherent similarity to other forms of prolonged fatigue made it desirable to devise guidelines that would facilitate comparative studies, i.e. studies aimed at discerning any features of CFS that serve to distinguish it from other forms of chronic fatigue. The authors have attempted to devise a comprehensive, systematic, and integrated approach to the evaluation, classification, and study of persons with CFS and other fatiguing illnesses. The article proposes a conceptual framework and a set of guidelines for conducting CFS studies. Included among the guidelines are recommendations for the clinical evaluation of fatigued persons, and a strategy for subgrouping fatigued persons for scientific investigations.
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