The Registry of Toxic Effects of Chemical Substances
Isocyanic acid, methylene (3,5,5 - trimethyl - 3,1 - cyclohexylene) ester |
UPDATE: May 2008 | MW: 222.32 | MF: C12H18N2O2 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | mouse
lowest published toxic dose: 415 mg/kg (8-12 day pregnant)
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Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
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WDZAEK 5,178,1991
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | guinea pig
lethal concentration (50 percent kill): 118 mg/m3/1 hour
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Behavioral: Somnolence (general depressed activity) | Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0543418
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inhalation | rat
lethal concentration (50 percent kill): 123 mg/m3/4 hour
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N/R
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85INA8 5,334(86),1986
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inhalation | rat
lowest published toxic concentration: 7.5 mg/m3/6 hour
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Lung, Thorax, or Respiration: Acute pulmonary edema | Lung, Thorax, or Respiration: Changes in lung weight
JAPTO* 24,231,2004
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inhalation | rat
lowest published toxic concentration: 2.1 mg/m3/6 hour
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Lung, Thorax, or Respiration: Other changes
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JAPTO* 24,231,2004
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inhalation | rat
lowest published toxic concentration: 7.5 mg/m3/6 hour
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Nutritional and Gross Metabolic: Body temperature decrease
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JAPTO* 24,231,2004
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oral | cat
lethal dose (50 percent kill): 1 mL/kg
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N/R
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NTIS** OTS0528418
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oral | mouse
lowest published lethal dose: 2,500 µL/kg
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N/R
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NTIS** OTS0528418
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oral | rat
lethal dose (50 percent kill): 4,825 mg/kg
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N/R
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NTIS** OTS0530238
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skin | rat
lowest published lethal dose: 1 mL/kg
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N/R
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NTIS** OTS0528418
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lowest published toxic concentration: 1,370 µg/m3/4 hour/4 week- intermittent
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Lung, Thorax, or Respiration: Changes in lung weight | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0528418
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skin | mouse
lowest published toxic dose: 0.3 pph/2 day- intermittent
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Blood: Other changes | Skin: After topical application: Cutaneous sensitization (experimental)
TOXID9 72,101,2003
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skin | mouse
lowest published toxic dose: 220 mg/kg/12 day- intermittent
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Skin: After topical application: Cutaneous sensitization (experimental) | Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 207,487,2005
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skin | mouse
lowest published toxic dose: 1 pph/5 day- continuous
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Skin: After systemic exposure: Dermatitis, irritative
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NTPTR* IMM-90001.
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skin | mouse
lowest published toxic dose: 480 mg/kg/28 day- intermittent
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Immunological Including Allergic: Increase in humoral response
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TOSCF2 94,108,2006
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REVIEWS:
ORGANIZATION
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STANDARD
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| REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 0.005 ppm
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DTLVS* TLV/BEI,2007
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TOXICOLOGY REVIEW
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TOLED5 140-141,213,2003
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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| REFERENCE
Occupational Exposure Limit - BELGIUM
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time-weighted average 0.005 ppm (0.045 mg/m3), Skin, JAN1993
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Occupational Exposure Limit - DENMARK
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time-weighted average 0.005 ppm (0.045 mg/m3), OCT 2002
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Occupational Exposure Limit - FRANCE
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VME 0.01 ppm (0.09 mg/m3), VLE 0.02 ppm (0.18 mg/m3), FEB2006
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Occupational Exposure Limit - GERMANY
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MAK 0.046 mg/m3 (0.005 mL/m3) (airway, skin, sen), 2005
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Occupational Exposure Limit - KOREA
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time-weighted average 0.005 ppm (0.045 mg/m3), skin, 2006
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Occupational Exposure Limit - MEXICO
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time-weighted average 0.01 ppm (0.09 mg/m3), 2004
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 0.05 mg/m3, 2003
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Occupational Exposure Limit - NORWAY
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time-weighted average 0.005 ppm (0.045 mg/m3), JAN1999
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Occupational Exposure Limit - SWEDEN
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time-weighted average 0.002 ppm (0.018 mg/m3), ceiling concentration 0.005 ppm (0.046 mg/m3), Sen, JUN2005
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Occupational Exposure Limit - SWITZERLAND
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MAK- week 0.005 ppm (0.02 mg/m3),KZG- week 0.005 ppm (0.02 mg/m3), DEC2006
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | time-weighted average 0.005 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
time-weighted average 0.005 ppm |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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| REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IPDI-air
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10 hour time-weighted average 0.005 ppm (Sk); | short term exposure limit 0.02 ppm (Sk)
NIOSH* DHHS #92-100,1992
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National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 83571; | Number of Industries 4; Total Number of Facilities 111; Number of Occupations 19; Total Number of Employees Exposed 3,441
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 83571; |
Number of Industries 15; Total Number of Facilities 1,186; Number of Occupations 16; Total Number of Employees Exposed 7,245; Total Number of Female Employees Exposed 682 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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| REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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| REFERENCE
85INA8
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"Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed.,
Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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JAPTO*
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Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex,
PO22 9SA England) V.1- 1981-
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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NTPTR*
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National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709)
No.206-
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TOLED5
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Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
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TOSCF2
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Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 )
V. 41, Jan. 1998-
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TOXID9
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Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
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TXCYAC
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Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
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WDZAEK
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Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu,
Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987
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