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 Thursday, January 5, 2006     Volume 16   Number 1  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Spotlight
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EGAPP Meeting Agenda
The next EGAPP Working Group meeting is scheduled for February 13-14, 2006 in Atlanta, Georgia. The preliminary agenda is posted and observers are welcome at the open session on Monday.

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CDC Announcements
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A road map for efficient and reliable human genome epidemiology This reference links to a non-governmental website
John P A Joannidis, Marta Gwinn, Julian Little, et al.
Nature Genetics 38, 305 (2006)
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New HuGE Review
EPHX1 Polymorphisms and the Risk of Lung Cancer
Chikako Kiyohara, et al.

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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Breakdown of myelin linked to genetic risk of Alzheimer's disease” This reference links to a non-governmental website
(January 2) News-Medical.net reports, “A new UCLA imaging study shows that age-related breakdown of myelin, the fatty insulation coating the brain's internal wiring, correlates strongly with the presence of a key genetic risk factor for Alzheimer disease.”

“Coffee Consumption Reduces Breast Cancer Risk For Women With Genetic Mutation, Study Says” This reference links to a non-governmental website
(January 5) Medical News Today reports, “Consumption of caffeinated coffee significantly reduces the risk of developing breast cancer among women who have a specific genetic mutation that greatly increases the chance of being diagnosed with the disease, according to a study published in the Jan. 1 edition of the International Journal of Cancer, Reuters Health reports.”

“Genetics plays a role in the side effects experienced by people taking painkillers” This reference links to a non-governmental website
(January 4) EurekAlert! reports, “A study published in the January issue of the American Gastroenterological Association (AGA) journal Gastroenterology found a difference in how people responded to popular painkillers and that up to 30 percent of this variability can be attributed to an individual's genetic make-up.”

“Gene Plays Key Role in Stopping Spread of Some Cancers” This reference links to a non-governmental website
(January 4) InteliHealth reports, “Researchers have found a genetic reason for the aggressiveness of some cancers, and perhaps a pathway toward taming their spread.”

“Tandem transcripts team together” This reference links to a non-governmental website
(January 4) EurekAlert! reports, “In the January issue of the journal Genome Research, two teams of scientists describe a widespread phenomenon in the human genome called transcription-induced chimerism (TIC), where two adjacent genes produce a single, fused RNA transcript.”

“TUMOR TRAUMA: Unusual genetic disorder strikes children” This reference links to a non-governmental website
(January 3) The Patriot Ledger reports, “As 8-year-old Michelle Barron plays in her Canton living room, there’s no sign of her past trauma.”

“The impact of smoking and genes on rheumatoid arthritis” This reference links to a non-governmental website
(January 3) EurekAlert! reports, “Rheumatoid arthritis (RA) is one of the most common systemic autoimmune diseases, and one of the least understood. Smoking is the major known environmental risk factor for RA, though little is known about the mechanisms involved.”

“University sets up largest gene bank of ethnic minority groups” This reference links to a non-governmental website
(January 3) China View reports, “The largest gene bank of Chinese ethnic minority groups has been set up at Yunnan University in southwest China's Yunnan Province, according to sources with university.”

“Researchers discover how a gene linked to Parkinson’s disease can keep brain cells alive” This reference links to a non-governmental website
(December 29) News-Medical.net reports, “Researchers at the University of Colorado at Denver and Health Sciences Center's School of Medicine have uncovered how a gene linked to Parkinson's disease can keep brain cells alive.”

“Genetic screening could save kids' lives” This reference links to a non-governmental website
(December 27) myDNA reports, “Italian researchers have developed a novel approach for genetic screening for long QT syndrome (LQTS), an inherited disease that predisposes young individuals to cardiac arrhythmias and sudden death, according to a study in the Dec. 21 issue of The Journal of the American Medical Association (JAMA).”

“Stem cells fight sickle cell?” This reference links to a non-governmental website
(December 27) myDNA reports, “In a study to be published in the January 2006 issue of Nature Biotechnology, researchers led by a team of scientists at Memorial Sloan-Kettering Cancer Center have devised a novel strategy that uses stem cell-based gene therapy and RNA interference to genetically reverse sickle cell disease (SCD) in human cells.”

“Twins Comparison Suggests Genetic Risk For Dementia” This reference links to a non-governmental website
(December 27) Medical News Today reports, “On average, twins of people who have been diagnosed with dementia score lower on cognitive tests than do the twins of people without dementia, new research has found.”

“New Members Of The Human Genetics Commission Appointed, UK” This reference links to a non-governmental website
(December 27) Medical News Today reports, “UK Health Minister Jane Kennedy and Science Minister Lord Sainsbury today announced the appointment of seven new members to the Human Genetics Commission.”

“Asthma, obesity linked by genetics” This reference links to a non-governmental website
(December 23) myDNA reports, “University of Washington researchers have found a strong genetic link between asthma and obesity.”

“Successful Aging May Be Partly in the Genes” This reference links to a non-governmental website
(December 23) Reuters Health reports, “If you make it to a ripe old age with all your marbles, credit might go to the gene you inherited.”

 
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Genomics in Scientific Literature
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Database resources of the National Center for Biotechnology Information
Wheeler DL, et al.
Nucleic Acids Res 2006 Jan;34(Database issue):D173-80

Family History of Stroke Does Not Predict Risk of Stroke After Transient Ischemic Attack
Flossmann E & Rothwell PM
Stroke 2005 Dec

Clinical Guidelines for Psychiatrists for the Use of Pharmacogenetic Testing for CYP450 2D6 and CYP450 2C19
de Leon J, et al.
Psychosomatics 2006 Jan-2006 Feb;47(1):75-85

Ethical guidelines in genetics and genomics. An Islamic perspective
Al-Aqeel AI
Saudi Med J 2005 Dec;26(12):1862-70

Confronting ethnicity-specific disease risk
Tang H
Nat Genet 2006 Jan;38(1):13-5

Impact of genetic counseling and DNA testing on individuals with colorectal cancer with a positive family history: a population-based study
Loader S, et al.
Genet Test 2005 Winter;9(4):313-9

Recruitment, Genetic Counseling, and BRCA Testing for Underserved Women at a Public Hospital
Lee R, et al.
Genet Test 2005 Winter;9(4):306-12

Referral and experience with genetic testing among women with early onset breast cancer
Brown KL, et al.
Genet Test 2005 Winter;9(4):301-5

Apolipoprotein E variants and cognition in healthy individuals: A critical opinion
Savitz J, et al.
Brain Res Brain Res Rev 2005 Dec

Future contributions on genetics
Krebs MO
World J Biol Psychiatry 2005;6 Suppl 2:49-55

Genetics of community-acquired pneumonia
Wunderink RG & Waterer GW
Semin Respir Crit Care Med 2005 Dec;26(6):553-62

Perceptions and Attitudes about HFE Genotyping Among College-Age Adults
Hicken BL, et al.
J Genet Couns 2005 Dec

Risk-Reduction Surgery Decisions in High-Risk Women Seen for Genetic Counseling
Ray JA, et al.
J Genet Couns 2005 Dec

Psychological Adjustment and Knowledge About Hereditary Hemochromatosis in a Clinic-Based Sample: A Prospective Study
Meiser B, et al.
J Genet Couns 2005 Dec

Corticosteroid receptor genetic polymorphisms and stress responsivity
Derijk R & de Kloet ER
Endocrine 2005 Dec;28(3):263-70

The Use of Genetic SNPs as New Diagnostic Markers in Preventive Medicine
Cantor CR
Ann N Y Acad Sci 2005 Dec;1055:48-57

Variants Associated with Common Disease Are Not Unusually Differentiated in Frequency across Populations
Lohmueller KE, et al.
Am J Hum Genet 2006 Jan;78(1):130-6

           
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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending January 4, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

 
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Upcoming Events
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New this week

2006 Annual Clinical Genetics Meeting This reference links to a non-governmental website (last accessed 2/2008)
March 23-26, 2006 ~ San Diego, California

American Association for the Advancement of Science (AAAS) Annual Meeting This reference links to a non-governmental website
February 16-20, 2006 ~ St. Louis, Missouri

   
New this week

[First Ever] National Conference on Trisomy X and XYY This reference links to a non-governmental website
March 3-5, 2006 ~ Sacramento, California

   
 

Second American Congress of Epidemiology
June 21-24, 2006 ~ Seattle, WA

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Let's Go Surfing
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Genomics at Food and Drug Administration (FDA)   This reference links to a non-governmental website
Several guidance documents are being developed that provide information on the FDA’s current thinking and the use of pharmacogenomics for regulatory decision making.

International Society of Nurses in Genetics (ISONG) This reference links to a non-governmental website
ISONG, the International Society of Nurses in Genetics, is a nursing specialty organization dedicated to fostering the scientific and professional growth of nurses in human genetics.

New York University (NYU) Cancer Institute (CI) Genomics Facility This reference links to a non-governmental website
“The NYU CI Genomics Facility is a fee-for-service laboratory operated by the NYU Cancer Institute as a Core Resource for the NYU School of Medicine.”

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: January 5, 2006 (archived document)
Page last updated: November 6, 2007
Content Source: National Office of Public Health Genomics