New report, “Family history as a risk factor for common, complex disease,”  produced by the PHG Foundation. Author: Adam Butterworth.
	New podcast, “Family History – An Early Warning for Your Child,” produced by CDC’s National Center on Birth Defects and Developmental Disabilities.
	New Genomics Forum of the American Public Health Association was approved this month. Interested individuals can join for free
	The Secretary’s Advisory Committee on Genetics, Health, and Society invites input on the Committee’s draft report, U.S. System of Oversight of Genetic Testing: A Response to the Charge of the Secretary of HHS, by December 21, 2007.

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.
  

PedGenie: meta genetic association testing in mixed family and case-control designs
Curtin K, et al.
BMC Bioinformatics 2007 Nov;8(1):448

MDRView: a visualization of the polymorphisms of MDR1(ABCB1) GENE in breast cancer
Edlira X, et al.
Conf Proc IEEE Eng Med Biol Soc 2007;1:4592-4

Negative Selection on BRCA1 Susceptibility Alleles Sheds Light on the Population  Genetics of Late-Onset Diseases and Aging Theory
Pavard S & Metcalf CJ
PLoS ONE 2007;2(11):e1206

Race, genetics and medicine: does the color of a leopard's spots matter?
Bamshad M & Guthery SL
Curr Opin Pediatr 2007 Dec;19(6):613-8

The genetic basis of psoriasis
Valdimarsson H
Clin Dermatol 2007 Nov-2007 Dec;25(6):563-7

Studies of association in complex diseases: Statistical problems related to the  analysis of genetic polymorphisms
Salas A & Carracedo A
Rev Clin Esp 2007 Dec;207(11):563-5

CYP2D6 polymorphism: implications for antipsychotic drug response, schizophrenia  and personality traits
Dorado P, et al.
Pharmacogenomics 2007 Nov;8(11):1597-608

Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations
Fackenthal JD & Olopade OI
Nat Rev Cancer 2007 Dec;7(12):937-48

Breakthroughs in genetic studies of ankylosing spondylitis
Brown MA
Rheumatology (Oxford) 2007 Nov

Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes
Nordgard SH, et al.
Breast Cancer Res 2007 Nov;9(6):113

beta-Adrenergic receptor polymorphisms: relationship to the beta-agonist controversy and clinical implications
Taylor DR
Expert Opin Pharmacother 2007 Dec;8(18):3195-203

Pharmacogenomics in prevention of diabetic cardiovascular disease: utilization of the haptoglobin genotype in determining benefit from vitamin E
Levy AP & Blum S
Expert Rev Cardiovasc Ther 2007 Nov;5(6):1105-11

Family history of diabetes, autoimmunity, and risk factors for cardiovascular disease among children with diabetes in the SEARCH for Diabetes in Youth Study
Gilliam LK, et al.
Pediatr Diabetes 2007 Dec;8(6):354-61

Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
Mosconi L, et al.
Proc Natl Acad Sci U S A 2007 Nov

Parental history of Type 2 diabetes in patients with nonaffective psychosis
Fernandez-Egea E, et al.
Schizophr Res 2007 Nov

Sex Differences in Heritability of Ischemic Stroke. A Systematic Review and Meta-Analysis
Touze E & Rothwell PM
Stroke 2007 Nov

MRI Screening in a Clinic Population with a Family History of Breast Cancer
Yu J, et al.
Ann Surg Oncol 2007 Nov

Family History of Cancer and Risk of Lung Cancer among Nonsmoking Chinese Women
Zhang Y, et al.
Cancer Epidemiol Biomarkers Prev 2007 Nov;16(11):2432-5

Sex- and Kindred-Specific Familial Risk of Non Hodgkin's Lymphoma
Czene K, et al.
Cancer Epidemiol Biomarkers Prev 2007 Nov;16(11):2496-9

Aggregation of cancer in first-degree relatives of patients with glioma
Scheurer ME, et al.
Cancer Epidemiol Biomarkers Prev 2007 Nov;16(11):2491-5

 

Cancer Risk Management Practices of Noncarriers Within BRCA1/2 Mutation Positive  Families in the Kathleen Cuningham Foundation Consortium for Research Into Familial Breast Cancer
Dawson SJ, et al.
J Clin Oncol 2007 Nov

Cancer risk reduction and reproductive concerns in female BRCA1/2 mutation carriers
Staton AD, et al.
Fam Cancer 2007 Nov

Genetic testing for melanoma predisposition: current challenges
Gerstenblith MR, et al.
Cancer Nurs 2007 Nov-2007 Dec;30(6):452-9

Results communication and patient education after screening for possible hemochromatosis and iron overload: experience from the HEIRS Study of a large ethnically and linguistically diverse group
Walker AP, et al.
Genet Med 2007 Nov;9(11):778-91

Barriers to participating in genetic counseling and BRCA testing during primary treatment for breast cancer
Schlich-Bakker KJ, et al.
Genet Med 2007 Nov;9(11):766-77

Toxicogenetics of antiretroviral therapy: genetic factors that contribute to metabolic complications
Tarr PE & Telenti A
Antivir Ther 2007;12(7):999-1013

Assessing hypothetical scenario methodology in genetic susceptibility testing analog studies: a quantitative review
Persky S, et al.
Genet Med 2007 Nov;9(11):727-38

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending November 28, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page