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 Thursday, February 14, 2008 Volume 20   Number 7
Update banner Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genomic research on disease prevention & population health. open mailbox for email deliveryGet email updates
Spotlight
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Letting the Genome Out of the Bottle — Will We Get Our Wish?
New genomic technologies are becoming readily available to the general public; however, little objective information exists to guide clinical or public health decision-making about their effectiveness or appropriate use.

February is American Heart Month
Heart disease is the leading cause of death in the United States and a major cause of disability. To raise awareness of this disease, since 1963, Congress has requested that the President proclaim February as “American Heart Month.”

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Sections

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blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
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 Let's Go Surfing

February is American Heart Month, CDC

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Ontario Genomics Institute non-gov warning icon


Genomics Announcements
 
CDC sponsored material
CDC is sponsoring an ASHG Genetics and Public Health Research and Practice Program fellowship to enhance CDC’s current activities and develop new approaches in integrating genetics and genomics into public health policy and programs at the national, state, and local levels. For more information, visit the American Society of Human Genetics (ASHG) website. The deadline to apply is March 15, 2008.
   
CDC sponsored material
CDC's National Office of Public Health Genomics seeks a new geneticist. For more information about this position, click on the U.S. Department of Health and Human Services website and enter the vacancy number (HHS-CDC-T2-2008-0158 – for current employees or HHS-CDC-D2-2008-0091 – for non-federal applicants). The deadline to apply is February 15, 2008.
   
CDC sponsored material
CDC's National Office of Public Health Genomics announces a new funding opportunity for those interested in genomics translation research.
Final applications are due: February 27, 2008. If you have questions, please contact Brenda Colley-Gilbert at 770/488-8390 or bjc4@cdc.gov.
   
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New journal, Public Health Genomicsnon-gov warning icon (a continuation of Community Genetics), expands the scope from medical genetics to include all topics related to the translation of genome-based science into population health improvements.

   
CDC sponsored material
HuGENet™ What's New
February 2008


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

MMP-2 gene variants increase cervical cancer
risk
, non-gov warning icon medwirenews, February 13

Cancer cells adapt using Darwin's 'survival of the fittest' principle to resist treatment, non-gov warning icon News-Medical.Net, February 11

Prostate cancer genetics, non-gov warning icon Medical News Today, February 12

Research to examine connection between cancer, genetics among American Indians, non-gov warning icon Medical News Today, February 11

Gene therapy activates immune system in patients with leukemia, non-gov warning icon Medical News Today, February 12

Board of Health urges early cancer detection, non-gov warning icon The Paramus Post, February 7

Benefit of cancer prevention surgery differs between women with BRCA1 and BRCA2 mutations, non-gov warning icon Medical News Today, February 12

Henry Ford Hospital expands research on gene and radiation therapy for prostate cancer, non-gov warning icon News-Medical.Net, February 7

deCODE Genetics launches test for prostate
cancer
, non-gov warning icon Washington G-2 Reports, February 11

 

line

Cardiovascular Disease

Don't let heart disease spread from generation to generation, non-gov warning icon Cape Cod Times, February 14 Discovery of gene locus associated with cardiovascular disease raises hope of new treatments, non-gov warning icon Cordis, February 11

line

Diabetes

Diabetes worsens with impaired fat-burning gene, non-gov warning icon Medical News Today, February 8

line

Ethical, Legal and Social Issues (ELSI)

Body 2.0: Changing the nature of genetic data, non-gov warning icon TechNewsWorld, February 8

So you want to know your genome, non-gov warning icon Duke Today, February 8

line

Family History

New web site helps healthcare providers know your family health history, non-gov warning icon wsaw.com, February 8

line

Genetic Testing

flexSCAN, Inc. announces geneVIEW(TM) -- Free genetic testing, non-gov warning icon Yahoo, February 13

Is a gene test right for you, non-gov warning icon The Arizona Republic, February 12

The downside of DNA testing, non-gov warning icon Nightly News, February 12

 

line

Mental Health

Obesity

Genizon BioSciences collaborating with London Genetics to enhance gene discovery findings in schizophrenia, non-gov warning icon Medical News Today, February 11

Nature tops nurture in childhood obesity: Study, non-gov warning icon abc News, February 7

line

Other News

The importance of gene location, non-gov warning icon Medical News Today, February 14

Gene variant predicts medication response in patients with alcohol dependence, non-gov warning icon NIH News, February 7

Cigarette after Valentine snuggle deadlier for
some
, non-gov warning icon EurekAlert, February 13

New method reveals control, non-gov warning icon BiotechScandinavia, February 7

Race is on to produce a personal - and cheap - genome readout, non-gov warning icon International Herald Tribune, February 8

2 new LDL cholesterol genes found, non-gov warning icon Web MD, February 7

Scientists find how PARP-1 protein binds to genes and regulates human genome, non-gov warning icon News-Medical.Net, February 8

 
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Genomics in Scientific Literature
Featured Item

Large-Scale Evaluation of Genetic Variants in Candidate Genes for Colorectal Cancer Risk in the Nurses' Health Study and the Health Professionals' Follow-up Study
Hazra A, et al.
Cancer Epidemiol Biomarkers Prev 2008 Feb;17(2):311-9

 General Articles

Three generations of ongoing controversies concerning the use of short acting Beta-agonist therapy in asthma: a review
Jalba MS
J Asthma 2008 Jan-2008 Feb;45(1):9-18

COPD: A Pediatric Disease
Bush A
COPD 2008 Feb;5(1):53-67

WGAViewer: A Software for Genomic Annotation of Whole Genome Association Studies
Ge D, et al.
Genome Res 2008 Feb

Simple and efficient analysis of disease association with missing genotype data
Lin DY, et al.
Am J Hum Genet 2008 Feb;82(2):444-52

Psychological Factors Associated with Emotional Responses to Receiving Genetic Risk Information
Bennett P, et al.
J Genet Couns 2008 Feb

Pharmacogenetics: From Bench to Byte
Swen J, et al.
Clin Pharmacol Ther 2008 Feb

Prognostic Modelling in Ischaemic Stroke Study, Additional Value of Genetic Characteristics. Rationale and Design
Achterberg S, et al.
Eur Neurol 2008 Feb;59(5):243-52

Recent advances in the genetics of RA susceptibility
Bowes J & Barton A
Rheumatology (Oxford) 2008 Feb

 

 Genetic Testing

Carrier frequency of autosomal-recessive disorders in the Ashkenazi Jewish population: should the rationale for mutation choice for screening be reevaluated?
Fares F, et al.
Prenat Diagn 2008 Feb

Sharing Genetic Test Results in Lynch Syndrome: Communication With Close and Distant Relatives
Stoffel EM, et al.
Clin Gastroenterol Hepatol 2008 Feb

The impact of genetic testing for Crohn's disease, risk magnitude and graphical format on motivation to stop smoking: an experimental analogue study
Wright AJ, et al.
Clin Genet 2008 Feb

 

 Family History

Informing patients of familial diabetes mellitus risk: how do they respond? A cross-sectional survey
Qureshi N & Kai J
BMC Health Serv Res 2008 Feb;8(1):37

Family history: an essential tool for cardiovascular genetic medicine
Morales A, et al.
Congest Heart Fail 2008 Jan-2008 Feb;14(1):37-45

Familial aggregation of age-related macular degeneration in the Utah population
Luo L, et al.
Vision Res 2008 Feb;48(3):494-500

Recruitment strategies and comparison of prostate cancer-specific clinical data on African-American and Caucasian males with and without family history
Mandal DM, et al.
Prostate Cancer Prostatic Dis 2008 Feb

Family history of cancer as a risk factor for second malignancies after Hodgkin's lymphoma
Andersson A, et al.
Br J Cancer 2008 Feb

MSI is frequently recognized among gastric cancer patients with a family history  of cancer
Kanemitsu K, et al.
Hepatogastroenterology 2007 Dec;54(80):2410-4

Prediction of cardio- and cerebro-vascular events in patients with subclinical carotid atherosclerosis and low HDL-cholesterol
Rizzo M, et al.
Atherosclerosis 2008 Feb

 

 Genome-Wide Association Studies

On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants
Luca D, et al.
Am J Hum Genet 2008 Feb;82(2):453-63

Three genome-wide association studies and a linkage analysis identify HERC2 as a  human iris color gene
Kayser M, et al.
Am J Hum Genet 2008 Feb;82(2):411-23

Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
Gudmundsson J, et al.
Nat Genet 2008 Feb

Multiple newly identified loci associated with prostate cancer susceptibility
Eeles RA, et al.
Nat Genet 2008 Feb

Multiple loci identified in a genome-wide association study of prostate cancer
Thomas G, et al.
Nat Genet 2008 Feb

LDL-cholesterol concentrations: a genome-wide association study
Sandhu MS, et al.
Lancet 2008 Feb;371(9611):483-91

A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color
Sturm RA, et al.
Am J Hum Genet 2008 Feb;82(2):424-31

A genome-wide association scan for asthma in a general Australian population
Hui J, et al.
Hum Genet 2008 Feb

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending February 13, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

 

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Page last updated: February 14, 2008 (archived document)
Content Source: National Office of Public Health Genomics