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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
March 2, 2006
Volume 16, No. 9

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Infectious and Parasitic Diseases

Associations of the IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFN (gamma) R1 cytokine receptor genes with AIDS progression in a French AIDS cohort
Do H, et al.
Immunogenetics 2006 Feb

Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz
Wang J, et al.
Pharmacogenet Genomics 2006 Mar;16(3):191-8

 

Neoplasms

Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer
Zhang Y, et al.
Cancer Epidemiol Biomarkers Prev 2006 Feb;15(2):353-8

Catechol-O-methyltransferase Gene Polymorphisms in Benign Prostatic Hyperplasia and Sporadic Prostate Cancer
Tanaka Y, et al.
Cancer Epidemiol Biomarkers Prev 2006 Feb;15(2):238-44

Dietary Selenium Intake and Genetic Polymorphisms of the GSTP1 and p53 Genes on the Risk of Esophageal Squamous Cell Carcinoma
Cai L, et al.
Cancer Epidemiol Biomarkers Prev 2006 Feb;15(2):294-300

Risk of Colorectal Cancer in Monoallelic and Biallelic Carriers of MYH Mutations: A Population-Based Case-Family Study
Jenkins MA, et al.
Cancer Epidemiol Biomarkers Prev 2006 Feb;15(2):312-4

Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility
Yu JC, et al.
J Biomed Sci 2006 Feb

The CHEK2*1100delC Allelic Variant and Risk of Breast Cancer: Screening Results from the Breast Cancer Family Registry
Bernstein JL, et al.
Cancer Epidemiol Biomarkers Prev 2006 Feb;15(2):348-52

Variation in DNA Repair Genes ERCC2, XRCC1, and XRCC3 and Risk of Follicular Lymphoma
Ekstrom Smedby K, et al.
Cancer Epidemiol Biomarkers Prev 2006 Feb;15(2):258-65

Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias
Aydin-Sayitoglu M, et al.
Am J Hematol 2006 Feb;81(3):162-70

Association of CYP1A2 genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a high-risk region of China
Chen X, et al.
Pharmacogenet Genomics 2006 Mar;16(3):219-27

Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma
Schernhammer ES, et al.
Br J Cancer 2006 Feb

Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer
Lind H, et al.
Int J Cancer 2006 Feb

Genetic polymorphisms of Ataxia Telangiectasia Mutated affect lung cancer risk
Kim JH, et al.
Hum Mol Genet 2006 Feb

Joint Effects of the CYP1A1 MspI, ER{alpha} PvuII, and ER{alpha} XbaI Polymorphisms on the Risk of Breast Cancer: Results from a Population-Based Case-Control Study in Shanghai, China
Shen Y, et al.
Cancer Epidemiol Biomarkers Prev 2006 Feb;15(2):342-7

Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas
Zhongyin Z, et al.
Saudi Med J 2006 Feb;27(2):161-4

Genetic variants in epigenetic genes and breast cancer risk
Cebrian A, et al.
Carcinogenesis 2006 Feb

Nucleotide Excision Repair Gene Polymorphisms and Risk of Advanced Colorectal Adenoma: XPC Polymorphisms Modify Smoking-Related Risk
Huang WY, et al.
Cancer Epidemiol Biomarkers Prev 2006 Feb;15(2):306-11

Increased risk of non-small cell lung cancer and frequency of somatic TP53 gene mutations in Pro72 carriers of TP53 Arg72Pro polymorphism
Szymanowska A, et al.
Lung Cancer 2006 Feb

Single nucleotide polymorphisms in DNA repair genes and basal cell carcinoma of skin
Thirumaran RK, et al.
Carcinogenesis 2006 Feb

Esophageal squamous cell carcinoma and aldehyde dehydrogenase-2 genotypes in Japanese females
Yokoyama A, et al.
Alcohol Clin Exp Res 2006 Mar;30(3):491-500

Relationship between alpha-1 antitrypsin deficient genotypes S and Z and lung cancer in Jordanian lung cancer patients
El-Akawi ZJ, et al.
Saudi Med J 2006 Feb;27(2):181-4

Polymorphisms in TGF-beta1 gene and the risk of lung cancer
Kang HG, et al.
Lung Cancer 2006 Feb

 

Endocrine, Nutritional and Metabolic Diseases

Association between an IGF-I gene polymorphism and body fatness: differences between generations
Voorhoeve PG, et al.
Eur J Endocrinol 2006 Mar;154(3):379-88

Interleukin-6 g.-174G>C Promoter Polymorphism Is Associated with Obesity in the EPIC-Potsdam Study
Blakely EL, et al.
Pediatr Res 2006 Jan;14(1):14-8

Impact of variation in ADRB2, ADRB3, and GNB3 genes on body mass index and waist circumference in a Brazilian population
Mattevi VS, et al.
Am J Hum Biol 2006 Feb;18(2):182-6

Association of IL-18 promoter polymorphisms with predisposition to Type 1 diabetes
Mojtahedi Z, et al.
Diabet Med 2006 Mar;23(3):235-9

P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx
Buscher R, et al.
Pharmacogenet Genomics 2006 Mar;16(3):199-205

Associations of HLA-C alleles with multinodular goiters: study in a population from southeastern Spain
Rios A, et al.
Arch Surg 2006 Feb;141(2):123-8

Analysis of FOXO1A as a candidate gene for type 2 diabetes
Karim MA, et al.
Mol Genet Metab 2006 Feb

Association between angiotensin-converting enzyme insertion/deletion polymorphism and treatment response in type 2 diabetic patients
Salonen J, et al.
Eur J Intern Med 2006 Mar;17(2):115-9

Association of the -112A>C polymorphism of the uncoupling protein 1 gene with insulin resistance in Japanese individuals with type 2 diabetes
Fukuyama K, et al.
Biochem Biophys Res Commun 2006 Jan;339(4):1212-6

 

Diseases of the Blood and Blood-Forming Organs Disorders

HLA association is different in children and adults with severe acquired aplastic anemia
Fuhrer M, et al.
Pediatr Blood Cancer 2006 Feb

 

Mental Disorders

Sex Differences in the Influence of COMT Val158Met on Alcoholism and Smoking in Plains American Indians
Enoch MA, et al.
Alcohol Clin Exp Res 2006 Mar;30(3):399-406

Tryptophan Hydroxylase-1 Gene Variants Associate with a Group of Suicidal Borderline Women
Zaboli G, et al.
Neuropsychopharmacology 2006 Feb

Low Level of Response to Alcohol as Associated with Serotonin Transporter Genotype and High Alcohol Intake in Adolescents
Hinckers AS, et al.
Biol Psychiatry 2006 Feb

No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults
Surtees PG, et al.
J Psychiatr Res 2006 Feb

 

Diseases of the Nervous System and Sense Organs

Lack of Association between a GABA Receptor 1 Gene Polymorphism and Temporal Lobe Epilepsy
Stogmann E, et al.
Epilepsia 2006 Feb;47(2):437-9

Glutathione s-transferase m1, t1, and p1 gene polymorphism in exudative age-related macular degeneration: a preliminary report
Oz O, et al.
Eur J Ophthalmol 2006 Jan-2006 Feb;16(1):105-10

Multiple candidate gene analysis identifies {alpha}-synuclein as a susceptibility gene for sporadic Parkinson's disease
Mizuta I, et al.
Hum Mol Genet 2006 Feb

Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and tardive dyskinesia in patients with schizophrenia
Liou YJ, et al.
Pharmacogenet Genomics 2006 Mar;16(3):151-7

No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population
Scordo MG, et al.
Pharmacol Res 2006 Feb;53(2):162-5

Mutations of the puratrophin-1 (PLEKHG4) gene on chromosome 16q22.1 are not a common genetic cause of cerebellar ataxia in a European population
Wieczorek S, et al.
J Hum Genet 2006 Feb

Association of CYP2D6 and CYP1A2 gene polymorphism with tardive dyskinesia in Chinese schizophrenic patients
Fu Y, et al.
Acta Pharmacol Sin 2006 Mar;27(3):328-32

Delusion symptoms are associated with ApoE epsilon4 allelic variant at the early stage of Alzheimer's disease with late onset
Spalletta G, et al.
Eur J Neurol 2006 Feb;13(2):176-82

 

Diseases of the Circulatory System

Heart Rate Recovery after Maximal Exercise is Associated with Acetylcholine Receptor M2 (CHRM2) Gene Polymorphism
Hautala AJ, et al.
Am J Physiol Heart Circ Physiol 2006 Feb

Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients
Lepantalo A, et al.
Thromb Haemost 2006 Feb;95(2):253-9

Association of an estrogen receptor-alpha gene polymorphism with left ventricular mass
Leibowitz D, et al.
Blood Press 2006;15(1):45-50

Association analysis of genes in the renin-angiotensin system with subclinical cardiovascular disease in families with Type 2 diabetes mellitus: The Diabetes Heart Study
Burdon KP, et al.
Diabet Med 2006 Mar;23(3):228-34

Polymorphisms in four candidate genes in young patients with essential hypertension
Marcun Varda N, et al.
Acta Paediatr 2006 Mar;95(3):353-8

The Association Between Factor XIII Val34Leu Polymorphism and Early Myocardial Infarction
Hancer VS, et al.
Circ J 2006 Mar;70(3):239-42

 

Diseases of the Digestive System

DLG5 Variants in Inflammatory Bowel Disease
Buning C, et al.
Am J Gastroenterol 2006 Feb

NOD2/CARD15 in healthy relatives of IBD patients
Annese V, et al.
Eur Rev Med Pharmacol Sci 2006 Jan-2006 Feb;10(1):33-6

The polymorphism of multi-drug resistance 1 gene (MDR1) does not influence the pharmacokinetics of dexamethasone loaded into autologous erythrocytes of patients with inflammatory bowel disease
Annese V, et al.
Eur Rev Med Pharmacol Sci 2006 Jan-2006 Feb;10(1):27-31

Extreme heterogeneity in CARD15 and DLG5 Crohn disease-associated polymorphisms between German and Norwegian populations
Medici V, et al.
Eur J Hum Genet 2006 Feb

Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis
Mahurkar S, et al.
Gut 2006 Feb

 

Diseases of the Genitourinary System

Association of cryptorchidism with Gly146Ala polymorphism in the gene for steroidogenic factor-1
Wada Y, et al.
Fertil Steril 2006 Mar;85(3):787-90

Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nephropathy
McKnight AJ, et al.
J Hum Genet 2006 Feb

Estrogen receptor gene polymorphisms are associated with recurrence of endometriosis
Luisi S, et al.
Fertil Steril 2006 Mar;85(3):764-6

Role of interferon-gamma gene polymorphisms in susceptibility to IgA nephropathy: a family-based association study
Schena FP, et al.
Eur J Hum Genet 2006 Feb

 

Complications of Pregnancy, Childbirth, and the Puerperium

Correlation between plasminogen activator inhibitor-1 4G/5G polymorphism and pre-eclampsia: an appraisal
Wiwanitkit V
Arch Gynecol Obstet 2006 Mar;273(6):322-4

 

Diseases of the Skin and Subcutaneous Tissue

A Novel MGST2 Non-Synonymous Mutation in a Chinese Pedigree with Psoriasis Vulgaris
Yan KL, et al.
J Invest Dermatol 2006 Feb

 

Diseases of the Musculoskeletal System and Connective Tissue

Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients
Harrison P, et al.
Rheumatology (Oxford) 2006 Feb

CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasian populations
Huang QY, et al.
J Bone Miner Metab 2006;24(2):132-7

Association of HLA-DRB1*13 with susceptibility to uveitis in juvenile idiopathic arthritis in two independent data sets
Zeggini E, et al.
Rheumatology (Oxford) 2006 Feb

 

Congenital Anomalies

SLOS carrier frequency in Poland as determined by screening for Trp151X and Val326Leu DHCR7 mutations
Ciara E, et al.
Eur J Med Genet 2006 Feb

HLXB9 homeobox gene and caudal regression syndrome
Merello E, et al.
Birth Defects Res A Clin Mol Teratol 2006 Feb

Association between the Transforming Growth Factor Alpha Gene and Nonsyndromic Oral Clefts: A HuGE Review
Vieira AR
Am J Epidemiol 2006 Feb

 

Injury and Poisoning

PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity
Furlong CE, et al.
Pharmacogenet Genomics 2006 Mar;16(3):183-90

Association of renal function and delta-aminolevulinic acid dehydratase polymorphism among Vietnamese and Singapore workers exposed to inorganic lead
Chia SE, et al.
Occup Environ Med 2006 Mar;63(3):180-6

The Leiden mutation and activated protein C resistance as risk factors for disseminated intravascular coagulation in acutely poisoned patients
Prazanowski M, et al.
Clin Toxicol (Phila) 2006;44(1):53-7

 

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Page last reviewed: June 8, 2007 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics