New article “Size matters: just how big is BIG? Quantifying realistic sample size requirements for human genome epidemiology”  (479KB) published in the August 2008 issue of the International Journal of Epidemiology. Authors: Paul R. Burton, Anna L. Hansell, Isabel Fortier, Teri A. Manolio, Muin J. Khoury, Julian Little and Paul Elliott.
	The National Institutes of Health announces two new funding opportunities for genomics translation research: Implementation Planning Grants for Educational, Behavioral, or Social Studies for Translation of Genetic Factors in Common Diseases (U34) Translation of Common Disease Genetics into Clinical Applications (R21)

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Pathway analysis of seven common diseases assessed by genome-wide association Torkamani A, et al. Genomics 2008 Aug

Power for Genetic Association Study of Human Longevity Using the Case-Control Design
Tan Q, et al.
Am J Epidemiol 2008 Aug

Genetic risk factors in chronic pancreatitis
Sahin-Toth M, et al.
Orv Hetil 2008 Sep;149(36):1683-8

Genetic and epigenetic contributions to human nutrition and health: managing genome-diet interactions
Stover PJ & Caudill MA
J Am Diet Assoc 2008 Sep;108(9):1480-7

Pharmacogenetics in Psychiatry: Are We Ready for Widespread Clinical Use?
Arranz MJ & Kapur S
Schizophr Bull 2008 Aug

Host's Response in Otitis Media: Understanding Genetic Susceptibility
Ilia S, et al.
Pediatr Infect Dis J 2008 Aug

A Weighted-Holm Procedure accounting for allele frequencies in Genome-Wide Association Studies
Dalmasso C, et al.
Genetics 2008 Aug

Gene-Environment Interplay Between Cannabis and Psychosis
Henquet C, et al.
Schizophr Bull 2008 Aug

Establishment of an Australian National Genetic Heart Disease Registry
Ingles J, et al.
Heart Lung Circ 2008 Aug

The emerging genetic architecture of type 2 diabetes
Doria A, et al.
Cell Metab 2008 Sep;8(3):186-200

The Population Reference Sample, POPRES: A Resource for Population, Disease, and  Pharmacological Genetics Research
Nelson MR, et al.
Am J Hum Genet 2008 Aug

Factors associated with knowledge of genetics and nutritional genomics among dietitians
McCarthy S, et al.
J Hum Nutr Diet 2008 Aug

Genetic research on rare familial disorders: consent and the blurred boundaries between clinical service and research
Ponder M, et al.
J Med Ethics 2008 Sep;34(9):690-4

Warfarin pharmacogenetics
Limdi NA & Veenstra DL
Pharmacotherapy 2008 Sep;28(9):1084-97

New Standards and Enhanced Utility for Family Health History Information in the Electronic Health Record: An Update from the American Health Information Community's Family Health History Multi-Stakeholder Workgroup
Feero WG, et al.
J Am Med Inform Assoc 2008 Aug

Familial nasopharyngeal carcinoma in Hong Kong: epidemiology and implication in screening
Ng WT, et al.
Fam Cancer 2008 Aug

A population-based screening for microalbuminuria among relatives of CKD patients: the Kidney Evaluation and Awareness Program in Sheffield (KEAPS)
Bello AK, et al.
Am J Kidney Dis 2008 Sep;52(3):434-43

Decreased Cognition in Children with Risk Factors for Alzheimer's Disease
Bloss CS, et al.
Biol Psychiatry 2008 Aug

Family history is a significant risk factor for pancreatic cancer: results from a systematic review and meta-analysis
Permuth-Wey J & Egan KM
Fam Cancer 2008 Sep

 

Colorectal cancer cases and relatives of cases indicate similar willingness to receive and disclose genetic information
Ceballos RM, et al.
Genet Test 2008 Sep;12(3):415-20

BRCA1/2 in High-Risk African American Women with Breast Cancer: Providing Genetic Testing through Various Recruitment Strategies
Pal T, et al.
Genet Test 2008 Sep;12(3):401-7

Information and consent for newborn screening: practices and attitudes of service providers
Kerruish NJ, et al.
J Med Ethics 2008 Sep;34(9):648-52

Autistic phenotypes and genetic testing: state-of-the-art for the clinical geneticist
Lintas C & Persico AM
J Med Genet 2008 Aug

Genetic testing for asthma
Koppelman GH, et al.
Eur Respir J 2008 Sep;32(3):775-82

Genome-wide SNP-Based Linkage Scan Identifies a Locus on 8q24 for an Age-Related  Hearing Impairment Trait
Huyghe JR, et al.
Am J Hum Genet 2008 Aug

Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism
van den Oord EJ, et al.
Arch Gen Psychiatry 2008 Sep;65(9):1062-71

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
Kugathasan S, et al.
Nat Genet 2008 Aug

A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
Di Bernardo MC, et al.
Nat Genet 2008 Aug

Genome-Wide Association Analysis in Sarcoidosis and Crohn's Disease Unravels a Common Susceptibility Locus on 10p12.2
Franke A, et al.
Gastroenterology 2008 Jul

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending September 3, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue

For more information on HuGE, please visit the HuGENet™ home page