Johns Hopkins Medicine News

A Johns Hopkins transplant surgeon has found strong evidence that women over 45 are significantly less likely to be placed on a kidney transplant list than their equivalent male counterparts, even though women who receive a transplant stand an equal chance of survival.

New cells are born every day in the brain’s hippocampus, but what controls this birth has remained a mystery. Reporting in the January 1 issue of Science, neuroscientists at the Johns Hopkins University School of Medicine have discovered that the birth of new cells, which depends on brain activity, also depends on a protein that is involved in changing epigenetic marks in the cell’s genetic material.

New cells are born every day in the brain’s hippocampus, but what controls this birth has remained a mystery. Reporting in the January 1 issue of Science, neuroscientists at the Johns Hopkins University School of Medicine have discovered that the birth of new cells, which depends on brain activity, also depends on a protein that is involved in changing epigenetic marks in the cell’s genetic material.

The enzyme machine that translates a cell’s DNA code into the proteins of life is nothing if not an editorial perfectionist.

Pterosaurs have long suffered an identity crisis. Pop culture heedlessly — and wrongly — lumps these extinct flying lizards in with dinosaurs. Even paleontologists assumed that because the creatures flew, they were birdlike in many ways, such as using only two legs to take flight.

Digitalis-based drugs like digoxin have been used for centuries to treat patients with irregular heart rhythms and heart failure and are still in use today. In the Dec. 16 issue of the Proceedings of the National Academy of Sciences, researchers at the Johns Hopkins University School of Medicine now report that this same class of drugs may hold new promise as a treatment for cancer. This finding emerged through a search for existing drugs that might slow or stop cancer progression.

Johns Hopkins and other researchers report what is believed to be the first direct evidence in lab animals that the erectile dysfunction drug sildenafil amplifies the effects of a heart-protective protein.