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Sponsored by: |
Boston University |
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Information provided by: | Boston University |
ClinicalTrials.gov Identifier: | NCT00593216 |
The purpose of this study is to determine the potential usefulness of new functional MRI in diagnostic assessment of patients presenting with vertigo.
Condition | Intervention |
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Vertigo |
Device: Functional MRI imaging |
Study Type: | Observational |
Study Design: | Case Control, Retrospective |
Official Title: | New Diagnosis Of Vestibular Vertigo With Functional MRI |
Estimated Enrollment: | 20 |
Study Start Date: | July 2007 |
Estimated Study Completion Date: | December 2008 |
Estimated Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
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Healthy
Healthy volunteers devoid of any ear problems
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Device: Functional MRI imaging
The functional MRI imaging of whole brain will be obtained before, during and after the vestibular response which is induced by the designated caloric stimulation. Post-imaging analysis will reveal which region or neural pathways in the central nervous system may attributed to the development of vertigo.
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Vertigo
Patients with the symptoms of vertigo
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Device: Functional MRI imaging
The functional MRI imaging of whole brain will be obtained before, during and after the vestibular response which is induced by the designated caloric stimulation. Post-imaging analysis will reveal which region or neural pathways in the central nervous system may attributed to the development of vertigo.
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The incidence of vertigo has been reported to be as high as 1.5% in the general population and some reports suggest that more than 5% of adults experience some kind of vertigo each year. In 80% of affected individuals, this symptom resulted in a medical consultation, interruption of daily activities, or sick leave. Therefore, vertigo can have a significant impact on health and well being. Unfortunately, there is not yet any satisfactory objective method for diagnosis of vertigo. At present, the diagnosis usually depends on medical history, vestibular function tests, Dix-Hallpike positioning tests done in the office, and, to some extent imaging studies doen to look for such abnormalities such as acoustic tumor, brain tumor, and evidence of multiple sclerosis. A number of recent studies support the possibility of using functional MRI (fMRI), particularly a new diffusion tensor fiber tracking (DTT) technique, as a new tool for diagnosis of disorders that can cause vertigo. In this study, our hypothesis is that there is an alteration in the activity in neural pathways of patients with vertigo that can be detected by fMRI. To test this assumption, our objective in this study is to determine whether there is a difference between the fMRI images obtained in normal subjects versus those in patients with vertigo.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
primary care clinic
Inclusion Criteria:
Exclusion Criteria:
United States, Massachusetts | |
Boston University Medical Center | |
Boston, Massachusetts, United States, 02118 |
Principal Investigator: | Kenneth Grundfast, M.D. | Department of Otolaryngology- Head and Neck surgery of Boston University Medical Center |
Responsible Party: | Department of Surgery-Otolaryngology of Boston University Medical Center ( Kenneth Grundfast M.D. ) |
Study ID Numbers: | H-25852 |
Study First Received: | January 2, 2008 |
Last Updated: | August 5, 2008 |
ClinicalTrials.gov Identifier: | NCT00593216 |
Health Authority: | United States: Federal Government |
functional magnetic Resonance Imaging vertigo vestibular |
Signs and Symptoms Otorhinolaryngologic Diseases Neurologic Manifestations |
Vestibular Diseases Ear Diseases Vertigo |
Nervous System Diseases Labyrinth Diseases |