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Sponsors and Collaborators: |
University of Iowa National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | National Institute of Neurological Disorders and Stroke (NINDS) |
ClinicalTrials.gov Identifier: | NCT00271596 |
This research plan proposes to conduct a double-blind, placebo-controlled pilot clinical trial in 36 adults with mild Huntington's disease (HD) to address the following research aims:
Condition | Intervention | Phase |
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Huntington Disease Chorea |
Drug: 20mg qd citalopram or placebo |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Investigator), Placebo Control, Parallel Assignment, Efficacy Study |
Official Title: | A Randomized, Placebo-Controlled Pilot Study in Huntington's Disease (CIT-HD) |
Estimated Enrollment: | 36 |
Study Start Date: | November 2005 |
Estimated Study Completion Date: | March 2012 |
Estimated Primary Completion Date: | March 2012 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Experimental
20mg qd citalopram or placebo
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Drug: 20mg qd citalopram or placebo
a selective serotonin reuptake inhibitor (SSRI) treatment administered over 16 weeks
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Specific Aims:
Main Hypotheses:
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: William H Adams, BA | 319-353-4411 | William-H-Adams@uiowa.edu |
Contact: Nicole R Ramza, BA | 319-384-9408 | Nicole-Ramza@uiowa.edu |
United States, Iowa | |
The University of Iowa | Recruiting |
Iowa City, Iowa, United States, 52242 | |
Contact: William H Adams, BA 319-353-4411 William-H-Adams@uiowa.edu | |
Contact: Nicole R Ramza, BA 319-384-9408 Nicole-Ramza@uiowa.edu | |
Principal Investigator: Leigh J Beglinger, Ph.D. | |
Sub-Investigator: Jess G Fiedorowicz, M.D., M.S. |
Principal Investigator: | Leigh J Beglinger, Ph.D. | The University of Iowa Psychiatry Department |
Principal Investigator: | Jess G Fiedorowicz, M.D., M.S. | University of Iowa Psychiatry Department |
Responsible Party: | University of Iowa ( Leigh Beglinger, Ph.D. ) |
Study ID Numbers: | 200509746, 5K23NS055733-02 |
Study First Received: | December 30, 2005 |
Last Updated: | September 5, 2008 |
ClinicalTrials.gov Identifier: | NCT00271596 |
Health Authority: | United States: Federal Government |
Huntington Disease Citalopram Celexa |
Chorea Attention Focus |
Ganglion Cysts Huntington disease Basal Ganglia Diseases Central Nervous System Diseases Brain Diseases Neurodegenerative Diseases Citalopram Dyskinesias Serotonin Cognition Disorders Chorea |
Signs and Symptoms Delirium, Dementia, Amnestic, Cognitive Disorders Heredodegenerative Disorders, Nervous System Genetic Diseases, Inborn Mental Disorders Movement Disorders Neurologic Manifestations Dexetimide Dementia Huntington Disease Delirium |
Neurotransmitter Uptake Inhibitors Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Nervous System Diseases Physiological Effects of Drugs Psychotropic Drugs Serotonin Uptake Inhibitors |
Pharmacologic Actions Serotonin Agents Therapeutic Uses Antidepressive Agents, Second-Generation Central Nervous System Agents Antidepressive Agents |