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Sponsored by: |
University of Rochester |
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Information provided by: | University of Rochester |
ClinicalTrials.gov Identifier: | NCT00178360 |
The purpose of this study is primarily to assess the ability of a music therapy program to improve holistically the psychological, somatic, and social symptoms of patients with Huntington ’s disease (HD). We hope to demonstrate the benefits of applying music therapy interventions to the management methods of HD, thus paving the way for the development of an effective music therapy program for individuals with HD.
Condition | Intervention | Phase |
---|---|---|
Huntington's Disease |
Behavioral: Music Therapy |
Phase I |
Study Type: | Interventional |
Study Design: | Educational/Counseling/Training, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study |
Official Title: | The Effects of Music Therapy on Depression, Chorea and Other Symptoms of Huntington's Disease |
Estimated Enrollment: | 25 |
Study Start Date: | July 2004 |
Estimated Study Completion Date: | July 2005 |
ABSTRACT
Background: Recent studies show that music therapy helps improve the symptomatic manifestations of Parkinson’s Disease. Few studies have looked at music therapy as a treatment for the psychiatric, cognitive and motor symptoms of patients with Huntington’s disease (HD).
Objective: To examine the feasibility and tolerability of a treatment program of music therapy for patients with Huntington’s disease. Also, to determine if music therapy improves the mood and motor features of HD while improving quality of life.
Methods: Subjects with HD were recruited to participate in a six-week study that included one individual, half-hour music therapy session and one hour-long group session per week. The music therapy protocols were adapted from the Colorado State University’s Neurological Music Therapy program and were targeted to HD symptoms including balance and posture, fine motor skills, memory and attention, vocalizations, and mood. In particular the protocols included Rhythmic Auditory Stimulation (RAS), Pattern Sensory Enhancement (PSE), and Therapeutic Instrumental Music Playing (TIMP). Primary outcome of tolerability was to be assessed by the subjects’ adherence to the therapeutic protocol, attendance, and the results of an exit survey inquiring about their feelings toward the use of music therapy in HD. A secondary outcome of the study was the change in the Unified Huntington’s Disease Rating Scale (UHDRS) score between baseline and study completion.
Results: Five subjects were recruited for study participation (one female and four males). Music therapy was found to be a tolerable and feasible treatment for patients with HD (100% adherence and 98% attendance). Exit surveys demonstrated strongly positive feelings towards the music therapy treatment program in four of the five subjects (one survey was completed with contradictory answers by the subject). While there was improvement in UHDRS scores for finger tapping, pronation/supination and the Luria, these changes did not achieve statistical significance with the small sample size in this study.
Conclusions: Music therapy was well tolerated among subjects with HD in this small study. Future studies are now being planned to look at the efficacy of this intervention in a larger population of HD subjects.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Rosemary Oliva, BM | 585-273-2098 | Rosemary_Oliva@urmc.rochester.edu |
Contact: Olle Jane Z Sahler, MD | 585-275-3935 | OJ_Sahler@urmc.rochester.edu |
United States, New York | |
University of Rochester Medical Center | Recruiting |
Rochester, New York, United States, 14642 | |
Contact: Olle Jane Z Sahler, MD 585-275-3935 OJ_Sahler@urmc.rochester.edu | |
Contact: Rosemary Oliva, BM 585-273-2098 Rosemary_Oliva@urmc.rochester.edu | |
Sub-Investigator: Bryan C Hunter, PhD | |
Sub-Investigator: H. Christopher Hyson, MD | |
Sub-Investigator: Rosemary Oliva, BM | |
Sub-Investigator: Kori A LaDonna, BA |
Principal Investigator: | Olle Jane Z Sahler, MD | University of Rochester |
Study ID Numbers: | 10336 |
Study First Received: | September 12, 2005 |
Last Updated: | April 14, 2006 |
ClinicalTrials.gov Identifier: | NCT00178360 |
Health Authority: | United States: Institutional Review Board |
Huntington's Disease, Music Therapy, quality of life |
Depression Ganglion Cysts Huntington disease Basal Ganglia Diseases Quality of Life Central Nervous System Diseases Depressive Disorder Brain Diseases Neurodegenerative Diseases Dyskinesias |
Cognition Disorders Chorea Delirium, Dementia, Amnestic, Cognitive Disorders Heredodegenerative Disorders, Nervous System Genetic Diseases, Inborn Mental Disorders Movement Disorders Dementia Huntington Disease Delirium |
Nervous System Diseases |