Association between Manganese Exposure through Drinking Water and Infant Mortality in Bangladesh Danella Hafeman,1 Pam Factor-Litvak,1 Zhongqi Cheng,2 Alexander van Geen,2 and Habibul Ahsan1 1Mailman School of Public Health, Columbia University, New York, New York, USA; 2Lamont-Doherty Earth Observatory, Palisades, New York, USA Abstract Background: Manganese is a common natural contaminant of groundwater in Bangladesh. In this cross-sectional study we assessed the association between water manganese and all-cause infant mortality in the offspring of female participants in the Health Effects of Arsenic Longitudinal Study Cohort. Methods: In 2001, drinking water samples were collected, a history of well use was obtained, and a history of birth outcomes was ascertained. To avoid misclassification of exposure, women were included only if they had been drinking from the same well for most of their childbearing years (marriage years – well years ≤ 2) . Of a total of 26,002 births (among 6,537 mothers) , 3,837 children were born to women with this profile. The current analysis was based on the portion of these infants (n = 3,824) with recorded exposure and outcome status, 335 of whom died before reaching 1 year of age. Results: Infants exposed to water manganese greater than or equal to the 2003 World Health Organization standard of 0.4 mg/L had an elevated mortality risk during the first year of life compared with unexposed infants [odds ratio (OR) = 1.8 ; 95% confidence interval (CI) , 1.2–2.6]. Adjustment for water arsenic, indicators of social class, and other variables did not appreciably alter these results. When the population was restricted to infants born to recently married parents (marriage year1991 or after) , this elevation was more pronounced (OR = 3.4 ; 95% CI, 1.5–7.9) . Conclusions: These preliminary findings indicate a possible association between manganese exposure and infant mortality. However, given the methodologic limitations of this study, the association needs to be confirmed through future work. Key words: Bangladesh, drinking water, Health Effects of Arsenic Longitudinal Study, heavy metals, infant mortality, manganese. Environ Health Perspect 115:1107–1112 (2007) . doi:10.1289/ehp.10051 available via http://dx.doi.org/ [Online 27 March 2007] Address correspondence to D. Hafeman, Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 168th St, 7th Fl., 720.9, New York, NY 10032 USA. Telephone: (212) 305-6485. Fax: (212) 305-9413. E-mail: dmh2002@columbia.edu We thank the project staff and field workers in Bangladesh for their dedication and hard work. This research was supported by National Institutes of Health grants P42ES10349, P30ES09089, RO1CA107431, and RO1CA102484. The authors declare they have no competing financial interests. Received 3 January 2007 ; accepted 27 March 2007. The full version of this article is available for free in HTML or PDF formats. |