Epstein-Barr Virus as a Possible Cause for Chronic Fatigue Syndrome

This study is currently recruiting participants.

Verified by University of Mississippi Medical Center, May 2008

Sponsors and Collaborators:	University of Mississippi Medical Center Ohio State University
Information provided by:	University of Mississippi Medical Center
ClinicalTrials.gov Identifier:	NCT00433355

Purpose

The purpose of this study is to understand what causes a continuing fatigue for a long time with a number of symptoms occurring at the same time (Chronic Fatigue Syndrome-CFS). Epstein Barr Virus is among the group of viruses that have been associated with a continuing fatigue for a long time with a number of symptoms occurring at the same time, but the cause is still unknown.

Condition
Chronic Fatigue Syndrome

MedlinePlus related topics: Chronic Fatigue Syndrome

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case Control, Prospective
Official Title:	Studies on Epstein-Barr Virus as a Possible Etiological Agent for Chronic Fatigue Syndrome

Further study details as provided by University of Mississippi Medical Center:

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment:	150
Study Start Date:	December 2006
Estimated Study Completion Date:	October 2008

Detailed Description:

Epstein-Barr virus (EBV) is the etiological agent for heterophile positive infectious mononucleosis (IM). It is also an oncogenic herpes virus associated with African Burkitt's lymphoma (BL),nasopharyngeal carcinoma (NPC) and AIDS-associated B-cell lymphomas. EBV is also among a group of viruses that have been associated with chronic fatigue syndrome (CFS), although the etiology of CFS still remains unknown.Findings may lead to hypothesize that EBV enzymes, such as the dUTPase, have the capacity to induce immune dysregulation of the T-cell and NK cell responses and that this immune dysregulation produces immunopathology that results in the symptoms that we call CFS.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

18 y/o and above with history of CFS matched those without as to age and gender.

Criteria

Inclusion Criteria:

Healthy adults for controls.
Adults with chronic fatigue syndrome.

Exclusion Criteria:

Individuals with significant medical illness in reference to immunosuppressant drug.

Note: We recruit participants in the Mississippi area who could come in our site to provide blood draw.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00433355

Contacts

Contact: Sheila Belk, BS	601-815-5374	sbelk@medicine.umsmed.edu
Contact: Denise Montgomery, BS	601-815-5648	dmontgomery@medicine.umsmed.edu

Locations

United States, Mississippi
University of Mississippi Medical Center	Recruiting
Jackson, Mississippi, United States, 39216-4505
Principal Investigator: Gailen D. Marshall, M.D., PhD

Sponsors and Collaborators

University of Mississippi Medical Center

Ohio State University

Investigators

Principal Investigator:

Gailen D Marshall, M.D., PhD

University of Mississippi Medical Center

More Information

Responsible Party:	The University of Mississippi Medical Center ( Gailen D. Marshall, MD, PhD )
Study ID Numbers:	2006-0265
Study First Received:	February 7, 2007
Last Updated:	May 2, 2008
ClinicalTrials.gov Identifier:	NCT00433355
Health Authority:	United States: Institutional Review Board

Keywords provided by University of Mississippi Medical Center:

Chronic Fatigue Syndrome
Epstein-Barr Virus

Study placed in the following topic categories:

Virus Diseases
Signs and Symptoms
Muscular Diseases
Fatigue
Neuromuscular Diseases

Musculoskeletal Diseases
Myalgic encephalomyelitis
Central Nervous System Diseases
Encephalomyelitis
Fatigue Syndrome, Chronic

Additional relevant MeSH terms:

Pathologic Processes
Disease
Syndrome
Nervous System Diseases

ClinicalTrials.gov processed this record on January 16, 2009