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Study 20 of 25 for search of: | "Encephalomyelitis" |
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Sponsored by: |
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
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Information provided by: | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
ClinicalTrials.gov Identifier: | NCT00071162 |
The Fibromyalgia Family Study identifies and collects blood samples from families with two or more members affected with Fibromyalgia Syndrome (FMS). The primary goal of the study is to identify genes that predispose people to FMS and/or symptoms related to FMS; identifying these genes may lead to a better understanding of the disease and more effective treatments.
Condition |
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Fibromyalgia Irritable Bowel Syndrome Chronic Fatigue Syndrome Depression |
Study Type: | Observational |
Study Design: | Family-Based, Retrospective |
Official Title: | Fibromyalgia Family Study Registry |
DNA, whole blood
Enrollment: | 560 |
Study Start Date: | September 1999 |
FMS predominantly affects women and is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbance, and multiple tender points on physical examination. The pathophysiological mechanisms underlying FMS are not clearly understood, but neuroendocrine factors seem to be of major importance. Studies of familial association suggest that genetic factors play a role in FMS. This study will establish patterns of genetic linkage in families with FMS.
Participating family members will undergo a brief physical exam (including tender point exam), donate a blood sample, and complete a detailed questionnaire that includes experience with pain, fatigue, depression, bowel symptoms, headache, anxiety, and physical limitations. Measurements of serum serotonin and related compounds will also be obtained. To detect genetic factors, a genome-wide linkage scan using 405 microsatellite markers will be performed.
Ages Eligible for Study: | 12 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
The population of this study is family based and aimed to recruit 160 multic-case FMS families. We plan to perform a genome scan and evaluate 200-300 linkage markers to FMS and FMS-related traits. Future plans include establishing a DNA and data repository for distribution for future studies.
Inclusion Criteria
United States, Illinois | |
University of Illinois at Peoria | |
Peoria, Illinois, United States, 60612 | |
United States, Ohio | |
Case Western Reserve University | |
Cleveland, Ohio, United States, 44109 | |
University of Cincinnati | |
Cincinnati, Ohio, United States, 45221 | |
United States, Texas | |
University of Texas Health Sciences Center | |
San Antonio, Texas, United States, 78229 |
Study Chair: | Sudha Iyengar, PhD | Case Western Reserve University |
Responsible Party: | Case Western Reserve University ( Sudha Iyengar, PhD ) |
Study ID Numbers: | NIAMS-100 |
Study First Received: | October 14, 2003 |
Last Updated: | September 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00071162 |
Health Authority: | United States: Federal Government |
Pain Fatigue Sleep |
Depression Irritable Bowel Syndrome Chronic Fatigue Syndrome |
Gastrointestinal Diseases Colonic Diseases Pain Encephalomyelitis Fatigue Syndrome, Chronic Signs and Symptoms Musculoskeletal Diseases Neuromuscular Diseases Mental Disorders Irritable Bowel Syndrome Depression Fatigue Myofascial Pain Syndromes |
Fibromyalgia Myalgic encephalomyelitis Central Nervous System Diseases Rheumatic Diseases Depressive Disorder Intestinal Diseases Behavioral Symptoms Virus Diseases Muscular Diseases Digestive System Diseases Mood Disorders Colonic Diseases, Functional |
Pathologic Processes Disease Syndrome Nervous System Diseases |