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Sponsored by: |
University Hospital, Basel, Switzerland |
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Information provided by: | University Hospital, Basel, Switzerland |
ClinicalTrials.gov Identifier: | NCT00757913 |
Background: Delirium and long-term cognitive dysfunction (CD) are important complications of major surgery and intensive care treatment. Delirium is associated with increased mortality and CD has an important impact on mortality, independency, social interactions, and quality of life. Delirium is an important risk factor for the development of long-term CD. Particularly, patients aged 65 or older undergoing cardiac surgery are at a high risk of developing these problems. There are data suggesting that inflammation plays a key role in the development of delirium and possibly CD. It has been shown that n-3 fatty acids modulate the immune response of patients and have beneficial effects in abdominal surgery.
Working hypothesis: 1. Administration of n-3 enriched nutrition therapy including will modulate the inflammatory response and improve cognitive function after cardiac surgery.
Specific Aims: This project will test the impact of perioperative enteral n-3 fatty acids ProSure, Abbott Nutrition) in elderly patients undergoing elective cardiac surgery. Primary endpoint is CD one week postoperatively.
Methods: The investigators will investigate 400 patients aged 65 or older undergoing elective cardiac surgery. Half of these patients will receive supplementary of n-3 fatty acids to modulate the inflammatory response; the other half will receive an isocaloric nutritional supplement without n-3 fatty acids (Ensure Plus, Abbott Nutrition). Otherwise the treatment of the patients will not be influenced by this study. Cognitive function will be assessed preoperatively, 7 days and three months postoperatively. C-reactive protein, IL-6, IL-8, IL-10, S-100B, and neuron specific enolase will be monitored as markers of systemic inflammation and delirium.
Condition | Intervention | Phase |
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Delirium, Dementia, Amnestic, Cognitive Disorders Postoperative Cognitive Dysfunction |
Dietary Supplement: n-3 enriched nutrition |
Phase IV |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Parallel Assignment |
Official Title: | The Effect of n-3 Enriched Nutrition Therapy on Postoperative Cognitive Dysfunction and Delirium After Elective Cardiac Surgery |
Estimated Enrollment: | 400 |
Study Start Date: | September 2008 |
Arms | Assigned Interventions |
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1: Experimental
n-3 enriched nutrition
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Dietary Supplement: n-3 enriched nutrition |
2: Placebo Comparator
isocaloric nutrition without n-3 supplement
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Dietary Supplement: n-3 enriched nutrition |
Ages Eligible for Study: | 65 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Luzius A Steiner, MD PhD | ++41 (0)61 265 25 25 | lsteiner@uhbs.ch |
Switzerland | |
University Hospital Basel | Recruiting |
Basel, Switzerland, 4031 | |
Contact: Luzius A Steiner, MD PhD ++41 (0)61 265 25 25 lsteiner@uhbs.ch | |
Contact: Steiner | |
Principal Investigator: Luzius A Steiner, MD PhD | |
Sub-Investigator: Dagmar Birkner-Binder |
Principal Investigator: | Luzius A Steiner, MD, PhD | Department of Anaesthesia, University Hospital Basel, Switzerland |
Study ID Numbers: | EK 92/08 |
Study First Received: | September 22, 2008 |
Last Updated: | November 28, 2008 |
ClinicalTrials.gov Identifier: | NCT00757913 |
Health Authority: | Switzerland: Ethikkommission |
Signs and Symptoms Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Neurologic Manifestations Confusion |
Dementia Neurobehavioral Manifestations Cognition Disorders Delirium |
Nervous System Diseases |