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Sponsored by: |
Inverness Medical Innovations |
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Information provided by: | Inverness Medical Innovations |
ClinicalTrials.gov Identifier: | NCT00448968 |
The purpose of this study is to determine if levels of ischemia modified albumin (IMA) in blood are elevated in patients with suspected infection and are predictive of severity of illness in patients with sepsis.
In order to compare subjects with infection to those without infection who are representative of the ED population at each site, a group of non-infected control patients will be enrolled. Each hospital will enroll subjects with age (by decade) and sex matched controls to reflect the population of subjects suspected of infection.
Condition |
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Sepsis Severe Sepsis Systemic Inflammatory Response Syndrome Sepsis Syndrome |
Study Type: | Observational |
Study Design: | Screening, Cross-Sectional, Defined Population, Retrospective/Prospective Study |
Official Title: | The Utility of Ischemia Modified Albumin (IMA) in Sepsis |
Enrollment: | 150 |
Study Start Date: | March 2007 |
Study Completion Date: | September 2007 |
Sepsis is an unconquered challenge in medicine, affecting people of all ages and demographics. Severe sepsis affects approximately 751,000 patients in the United States per annum, with healthcare costs approaching $16.7 billion dollars a year. Mortality from severe sepsis and septic shock approaches 30 - 70 % with 215,000 deaths annually. Thus, sepsis is a disease with healthcare dollars and mortality rates approaching those of heart disease and cancer.
Identifying patients with sepsis, and in particular hypoperfusion, is a challenge to the clinician. A variety of clinical and laboratory findings are helpful, but there is no single test to identify sepsis or assess its severity.
Ischemia and reactive oxygen species play a significant role in the pathogenesis of sepsis. Moreover, there is evidence to suggest that septic shock results in dysfunction of autoregulatory mechanisms and misdistribution of blood flow, precipitating both regional and global ischemia. A method that can help rapidly assess hypoperfusion would be clinically useful. Ischemia modified albumin (IMA) is a potential marker for ischemia in acute coronary syndrome patients; thus, it is hypothesized that IMA may be also useful as a prognostic biomarker for clinical identification of infection and the severity of illness in patients with sepsis.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria for Sepsis Subjects:
Exclusion Criteria for Sepsis Subjects:
Inclusion Criteria for Control Subjects:
Exclusion Criteria for Control Subjects:
United States, Massachusetts | |
Beth Israel Deaconess Medical Center | |
Boston, Massachusetts, United States, 02215 | |
United States, Ohio | |
Cleveland Clinc | |
Cleveland, Ohio, United States, 44195 | |
United States, Pennsylvania | |
University of Pennsylvania School of Medicine | |
Philadelphia, Pennsylvania, United States, 19104 |
Principal Investigator: | Nathan Shapiro, M.D. | Beth Israel Deaconess Medical Center |
Principal Investigator: | Munish Goyal, M.D. | University of Pennsylvania |
Principal Investigator: | Rakesh Engineer, M.D. | Cleveland Clinic |
Study ID Numbers: | IMA-0806-003 |
Study First Received: | March 16, 2007 |
Last Updated: | September 26, 2007 |
ClinicalTrials.gov Identifier: | NCT00448968 |
Health Authority: | United States: Institutional Review Board |
Sepsis Ischemia Modified Albumin Systemic Inflammatory Response Syndrome |
Systemic Inflammatory Response Syndrome Sepsis Shock Ischemia Inflammation |
Disease Pathologic Processes Syndrome Infection |