The Combined Effect of 2,3-Dimercaptosuccinic Acid and Multi-Nutrients on Children in Lead Poisoning

This study has been completed.

Sponsored by:	China Medical University, China
Information provided by:	China Medical University, China
ClinicalTrials.gov Identifier:	NCT00374894

Purpose

Lead poisoning remains a common disease among children despite successful public health efforts that reduced its prevalence.Our study was designed to test the hypothesis that lead-poisoning children (BLLs:100-440µg/L) who were given DMSA and multi-nutrients would have a greater fall than children of other groups at 12 weeks of follow-up.

Condition	Intervention
Lead Poisoning	Drug: 2,3-dimercaptosuccinic acid

MedlinePlus related topics: Lead Poisoning Poisoning

Drug Information available for: Succimer

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Longitudinal, Defined Population, Prospective Study

Further study details as provided by China Medical University, China:

Estimated Enrollment:	500
Study Start Date:	March 2004
Estimated Study Completion Date:	August 2004

Eligibility

Ages Eligible for Study:	3 Years to 6 Years
Genders Eligible for Study:	Both

Criteria

Inclusion Criteria:

Initial BLLs 100-440µg/L
Age 3-6y
No more than two main residences
House cleaned (no lead contaminated)
Normal intake history and physical

Exclusion Criteria:

Chelation in the past 12 weeks
Concomitant Fe deficiency(ferritin<16ng/ml)
Hemoglobin<10.5g/dL
Medications affecting mineral metabolism

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00374894

Locations

China, Liaoning
China Medical University
Shenyang, Liaoning, China, 110001

Sponsors and Collaborators

China Medical University, China

Investigators

Study Director:

Jin Ya ping, professor

Department of Environmental and Occupational Health

More Information

Study ID Numbers:	20032063 - 2001102049
Study First Received:	September 11, 2006
Last Updated:	September 11, 2006
ClinicalTrials.gov Identifier:	NCT00374894
Health Authority:	China: Ministry of Health

Keywords provided by China Medical University, China:

2,3-dimercaptosuccinic acid
Blood Lead Levels
children
multi-nutrients

Study placed in the following topic categories:

Succimer
Lead Poisoning
Poisoning
Disorders of Environmental Origin

Additional relevant MeSH terms:

Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Chelating Agents

Protective Agents
Pharmacologic Actions
Antidotes

ClinicalTrials.gov processed this record on January 16, 2009