Exposure, Dose, Body Burden and Health Effects of Lead

This study is ongoing, but not recruiting participants.

Sponsored by:	National Institute of Environmental Health Sciences (NIEHS)
Information provided by:	National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:	NCT00013819

Purpose

This is a study of the effects that lead has on the health of the central nervous system (for example, memory), peripheral nervous system (for example, sensation and strength in the hands and fingers), kidneys, blood pressure, and the blood forming system. A total of 803 lead workers and 135 persons without occupational lead exposure are being studied in South Korea. Lead in the body is being assessed by measurement of blood lead, chelatable lead (an estimate of lead in the tissues), and lead in bone. Subjects are tested three times each over three years. Several genetic factors are also being assessed for the role they play in the health effects of lead. These genes are known to differ among individuals. We are interested to know whether different forms of the same genes can modify the effect lead has on health.

Condition
Lead Poisoning

MedlinePlus related topics: Lead Poisoning Poisoning

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Longitudinal, Defined Population, Prospective Study

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment:	944
Study Start Date:	February 1997
Estimated Study Completion Date:	February 2002

Eligibility

Ages Eligible for Study:	17 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Lead workers in South Korea in one of 26 specific lead-using facilities.

Population controls in South Korea.

Contacts and Locations

No Contacts or Locations Provided

More Information

Study ID Numbers:	7198-CP-001
Study First Received:	March 29, 2001
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00013819
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):

lead poisoning
central nervous system
peripheral nervous system
occupational health
genetic susceptibility

Study placed in the following topic categories:

Disease Susceptibility
Lead Poisoning
Poisoning
Disorders of Environmental Origin
Genetic Predisposition to Disease

ClinicalTrials.gov processed this record on January 16, 2009