Efficacy of Oral Colchicine in Prevention of Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment

This study is ongoing, but not recruiting participants.

Sponsored by:	Shaheed Beheshti Medical University
Information provided by:	Shaheed Beheshti Medical University
ClinicalTrials.gov Identifier:	NCT00370201

Purpose

This clinical trial will test the efficacy and safety of oral colchicine in prevention of proliferative vitreoretinopathy (PVR) in cases of rhegmatogenous retinal detachment

Condition	Intervention	Phase
Rhegmatogenous Retinal Detachment	Drug: colchicine	Phase III

Drug Information available for: Colchicine

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study

Further study details as provided by Shaheed Beheshti Medical University:

Primary Outcome Measures:

proliferative vitreoretinopathy
retinal reattachment rate

Secondary Outcome Measures:

visual acuity
reoperation
macular pucker

Study Start Date:	March 2004
Estimated Study Completion Date:	August 2006

Eligibility

Ages Eligible for Study:	18 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Rhegmatogenous retinal detachment

Exclusion Criteria:

PVR grade C
Duration of retinal detachment ≥ one month
History of cataract surgery
History of RD surgery

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00370201

Locations

Iran, Islamic Republic of
Hamid Ahmadieh,MD
Tehran, Iran, Islamic Republic of, 16666

Sponsors and Collaborators

Shaheed Beheshti Medical University

Investigators

Principal Investigator:

Hamid Ahmadieh, MD

Ophthalmic Research Center of Shaheed Beheshti Medical University

More Information

Study ID Numbers:	8259
Study First Received:	August 30, 2006
Last Updated:	October 6, 2006
ClinicalTrials.gov Identifier:	NCT00370201
Health Authority:	Iran: Ethics Committee

Keywords provided by Shaheed Beheshti Medical University:

retinal detachment
proliferative vitreoretinopathy

Study placed in the following topic categories:

Retinal Detachment
Eye Diseases
Colchicine
Vitreoretinopathy, Proliferative
Retinal Diseases

Additional relevant MeSH terms:

Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Therapeutic Uses
Mitosis Modulators
Tubulin Modulators

Antimitotic Agents
Antirheumatic Agents
Gout Suppressants
Pharmacologic Actions

ClinicalTrials.gov processed this record on January 16, 2009