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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR928 IGR931 IGR927 IGR925 IGR926 IGR930 IGR929 IGR924 phnA, - SMu1081 mtlA2, - SMu1083 msmK, - SMu1079 glnP, - SMu1080 atmA,abp,aatB, - SMu1078 mtlD, - SMu1082 mtlR, - SMu1084 pcrA, - SMu1075 ydaE, - SMu1077 dagA, - SMu1076 phnA, - SMu1081 mtlA2, - SMu1083 msmK, - SMu1079 glnP, - SMu1080 atmA,abp,aatB, - SMu1078 mtlD, - SMu1082 mtlR, - SMu1084 pcrA, - SMu1075 ydaE, - SMu1077 dagA, - SMu1076 phnA, - SMu1081 mtlA2, - SMu1083 msmK, - SMu1079 glnP, - SMu1080 atmA,abp,aatB, - SMu1078 mtlD, - SMu1082 mtlR, - SMu1084 pcrA, - SMu1075 ydaE, - SMu1077 dagA, - SMu1076


LANL Gene ID: SMu1079

GenBank Locus Tag: SMU.1178c

DNA Molecule Name:
1  

GenBank ID:
24379608

Gene Name:
msmK  

Definition:
amino acid ABC transporter, ATP-binding protein

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
1120418

Gene Stop:
1119789

Gene Length:
630

Molecular Weight*:
23423

pI*:
6.80

Net Charge*:
-0.55

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  

Gene Ontology:
Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Primary Evidence:
Russell,R.R.B., Aduse-Opuko,J., Sutcliffe,I.C., Tao,L. and
Ferretti,J.J.
A binding protein-dependent transport system in Streptococcus
mutans responsible for multiple sugar metabolism
J. Biol. Chem. 267, 4631-4637 (1992)
PubMed: 1537846

Russell RR, Ferretti JJ
Nucleotide sequence of the dextran glucosidase (dexB) gene of Streptococcus mutans.
J Gen Microbiol 1990 May;136 ( Pt 5):803-10
PubMed: 2380687
PMID: 2380687

Aduse-Opoku J, Tao L, Ferretti JJ, Russell RR
Biochemical and genetic analysis of Streptococcus mutans alpha-galactosidase.
J Gen Microbiol 1991 Apr;137 ( Pt 4):757-64
PubMed: 1649890
PMID: 1649890

Ferretti JJ, Huang TT, Russell RR
Sequence analysis of the glucosyltransferase A gene (gtfA) from Streptococcus mutans Ingbritt.
Infect Immun 1988 Jun;56(6):1585-8
PubMed: 2967248
PMID: 2967248

Waterhouse JC, Russell RR.
Dispensable genes and foreign DNA in Streptococcus mutans.
Microbiology. 2006 Jun;152(Pt 6):1777-88.
PMID: 16735740

Comment:
For other components see SMu1080 (MSD1) and SMu1078 (SBP1)

For other 'msm' genes see SMu0799 (msmR); SMu0801 (msmE); SMu0802 (msmF); SMu0803 (msmG); SMu0805 (msmK); SMu1428 (msmK); SMu0594 (msmK) and SMu0884 (msmK).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to amino acid ABC transporter:residues 2-204 are 37% similar to the previously published ATP-binding protein in S.mutans (gi153741).

Residues 1-209 are 74% similar to amino acid ABC transporter (ATP-binding protein) in S.pyogenes (gi15675230)





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0948 (5e-89).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379608|ref|NP_721563.1|  putative amino acid ABC transp...   394   e-108
 gi|55820918|ref|YP_139360.1|  polar amino acid ABC uptake tr...   320   3e-86
 gi|19746200|ref|NP_607336.1|  putative amino acid ABC transp...   311   2e-83
 gi|56808074|ref|ZP_00365869.1|  COG1126: ABC-type polar amin...   311   2e-83
 gi|94994529|ref|YP_602627.1|  Histidine transport ATP-bindin...   311   2e-83
 gi|94988717|ref|YP_596818.1|  histidine transport ATP-bindin...   310   4e-83
 gi|77413234|ref|ZP_00789431.1|  amino acid ABC transporter, ...   309   7e-83
 gi|25010990|ref|NP_735385.1|  hypothetical protein gbs0936 [...   309   7e-83
 gi|22537109|ref|NP_687960.1|  amino acid ABC transporter, AT...   309   8e-83
 gi|15675230|ref|NP_269404.1|  putative amino acid ABC transp...   308   9e-83


InterPro Summary:  InterProScan

InterPro
IPR003439
Domain
ABC transporter related
PD000006 [134-176]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [27-209]T 7.90003079443043E-58 PF00005 ABC_tran ABC_tran
PS00211 [134-148]T 8.0E-5 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [2-208]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [26-200]T 3.3000000000001004E-11 SM00382 AAA AAA
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [1-207]T 3.10001307370189E-62 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19222 [2-204]T 2.19999900980727E-86 PTHR19222 PTHR19222 PTHR19222
PTHR19222:SF33 [2-204]T 2.19999900980727E-86 PTHR19222:SF33 PTHR19222:SF33 PTHR19222:SF33
SSF52540 [1-207]T 2.2000000000000006E-65 SSF52540 SSF52540 SSF52540


COGS Summary:  COGS Search
BeTs to 7 clades of COG1126
COG name: ABC-type polar amino acid transport system, ATPase component
Functional Class: E
The phylogenetic pattern of COG1126 is a-----vcEB-Huj----inx
Number of proteins in this genome belonging to this COG is 7
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2.6e-32.
    IPB001140A    16-62
    IPB001140B    131-169


 ProDom Summary:  Protein Domain Search
Residues 22-207 are 27% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360 which is seen in Y121_METJA.

Residues 118-195 are 33% similar to a (ATP-BINDING PROTEOME COMPLETE 230AA) protein domain (PD169303 which is seen in Q9WW89_LACLC.

Residues 1-52 are 46% similar to a (TRANSPORT ATP-BINDING IRON CHELATIN) protein domain (PD351726 which is seen in Y888_HELPY.

Residues 18-65 are 58% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in POTA_HAEIN.

Residues 134-176 are 69% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in P74888_SALTY.

Residues 77-132 are 46% similar to a (ATP-BINDING PROTEOME AMINO COMPLETE) protein domain (PD194799 which is seen in O84132_CHLTR.


Paralogs:  Local Blast Search
SMu1079 is paralogously related (blast p-value < 1e-3) to SMu0849, SMu0517, SMu0731, SMu0218, SMu1380, SMu0418, SMu0594, SMu1920, SMu1003, SMu0884, SMu0805, SMu1428, SMu1288, SMu0216, SMu1762, SMu0971, SMu0390, SMu0786, SMu1210, SMu1246, SMu1231, SMu1068, SMu0235, SMu1949, SMu1518, SMu1751, SMu0335, SMu1517, SMu1023, SMu0916, SMu1950, SMu0596, SMu1036, SMu1001, SMu0234, SMu1093, SMu0374, SMu1649, SMu1757, SMu1037, SMu0825, SMu1064, SMu0950, SMu1065, SMu0258, SMu1316, SMu0976, SMu0907, SMu0164, SMu0024, SMu1410, SMu0944, SMu1710, SMu0986, SMu0476, SMu1306, SMu0475, SMu0224, SMu1959, SMu1545, SMu0837, SMu1724, SMu0836, SMu0752, SMu0987, SMu0823, SMu1811, SMu1050, SMu0729, SMu0824, SMu0666, SMu1202, and SMu1686, all with ATP binding capabilities.


Pfam Summary:  Pfam Search
Residues 27 to 209 (E-value = 1.3e-59) place SMu1079 in the ABC_tran family which is described as ABC transporter (PF00005)

 Top PDB Hits:
pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 146 3e-036
pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 146 3e-036

Gene Protein Sequence:
MLELKNISKQFGQKVIFNHFNLSIPEGKILSLVGPSGGGKTTLLRMLAGL
EKIDSGQVIYDDEVIAIEHLGHRNLLGFVFQDFQLFPHLTVLDNLILSPI
KSMNVSKEEAIQKARDLLKRLGLEEHENAYPYSLSGGQKQRVALARAMMV
NPKIIGYDEPTSALDPELRQEVEKLILQNQKLGITQIVVTHDMQFAQNIS
DEIVKINPK

Gene Nucleotide Sequence:  Sequence Viewer
ATGTTAGAGCTAAAAAACATTTCTAAGCAATTTGGTCAGAAGGTGATTTT
TAATCATTTTAATCTAAGCATCCCTGAAGGTAAAATCTTATCTTTGGTTG
GACCATCTGGTGGTGGTAAAACAACTTTGTTGCGCATGCTTGCAGGGCTG
GAAAAAATTGACTCTGGTCAAGTCATCTATGATGATGAAGTTATTGCTAT
TGAACATTTGGGACATCGCAACTTATTAGGTTTTGTTTTTCAAGACTTTC
AATTATTTCCGCATTTGACTGTTTTAGATAATTTGATTTTATCACCCATA
AAGTCTATGAATGTATCGAAAGAAGAAGCGATACAAAAAGCACGTGATCT
CTTAAAACGTTTAGGATTAGAGGAACATGAAAACGCTTATCCTTACTCTT
TATCAGGCGGTCAAAAACAGCGGGTAGCTTTGGCTCGTGCCATGATGGTT
AATCCTAAAATTATCGGCTATGATGAACCTACTAGTGCCTTAGATCCAGA
GTTAAGGCAGGAAGTTGAAAAATTAATTTTACAAAATCAAAAATTGGGTA
TCACACAAATTGTTGTGACACACGATATGCAGTTTGCCCAAAATATTTCT
GATGAGATTGTAAAAATCAATCCAAAATAA

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