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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR883 IGR882 IGR884 IGR881 IGR878 IGR879 SMu1028 deoC, - SMu1026 rnsD, - SMu1021 rnsB, - SMu1024 SMu1019 pdp, - SMu1027 nox-2,nox,naoX, - SMu1020 rnsA,psaA, - SMu1023 SMu1028 deoC, - SMu1026 rnsD, - SMu1021 rnsB, - SMu1024 SMu1019 pdp, - SMu1027 nox-2,nox,naoX, - SMu1020 rnsA,psaA, - SMu1023 Type: tandem, Name: SMu-TR-18 - 18 SMu1028 deoC, - SMu1026 rnsD, - SMu1021 rnsB, - SMu1024 SMu1019 pdp, - SMu1027 nox-2,nox,naoX, - SMu1020 rnsA,psaA, - SMu1023 cdd, - SMu1025 rnsC, - SMu1022 cdd, - SMu1025 rnsC, - SMu1022


LANL Gene ID: SMu1023

GenBank Locus Tag: SMU.1120c

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
rnsA  psaA  

Definition:
ribonucleoside ABC transporter, ATP-binding protein

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
1063932

Gene Stop:
1062400

Gene Length:
1533

Molecular Weight*:
55599

pI*:
6.10

Net Charge*:
-7.57

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  

Gene Ontology:
Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Primary Evidence:
Webb AJ, Hosie AH.
A member of the second carbohydrate uptake subfamily of ATP-binding cassette transporters is responsible for ribonucleoside uptake in Streptococcus mutans.
J Bacteriol. 2006 Dec;188(23):8005-12. Epub 2006 Sep 22.
PMID: 16997965

Comment:
For other components see SMu1022 (MSD1);SMu1021 (MSD2) and SMu1024 (SBP1).


View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to ABC transporter PsaA: residues 4-218 are 32% similar and residues 258-481 are 26% similar to the previously published protein in S.mutans (15625442|).Residues 1-510 are 80% similar to the protein from S.pyogenes (15675191|).Residues 3-510 are 75% similar to the protein from S.pneumoniae (15900733|).






The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0955 (0.0).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379552|ref|NP_721507.1|  putative sugar ABC transporter...   925   0.0  
 gi|71910754|ref|YP_282304.1|  nucleoside transport ATP-bindi...   805   0.0  
 gi|56807912|ref|ZP_00365738.1|  COG3845: ABC-type uncharacte...   804   0.0  
 gi|15675191|ref|NP_269365.1|  putative sugar ABC transporter...   803   0.0  
 gi|94988674|ref|YP_596775.1|  nucleoside transport ATP-bindi...   803   0.0  
 gi|21910403|ref|NP_664671.1|  putative sugar ABC transporter...   803   0.0  
 gi|19746160|ref|NP_607296.1|  putative sugar ABC transporter...   803   0.0  
 gi|28895979|ref|NP_802329.1|  putative sugar ABC transporter...   803   0.0  
 gi|94994486|ref|YP_602584.1|  Nucleoside transport ATP-bindi...   802   0.0  
 gi|71903578|ref|YP_280381.1|  nucleoside transport ATP-bindi...   801   0.0


InterPro Summary:  InterProScan

InterPro
IPR003439
Domain
ABC transporter related
PD000006 [143-184]T 0.0 PD000006 ABC_transporter[403-445]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [31-217]T 3.499994668639489E-48 PF00005 ABC_tran[284-478]T 2.7999988940408402E-14 PF00005 ABC_tran ABC_tran
PS00211 [403-417]? 0.0 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [6-241]T 0.0 PS50893 ABC_TRANSPORTER_2[258-502]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [30-218]T 3.5000000000002E-17 SM00382 AAA AAA
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [3-232]T 2.39999798157241E-63 G3DSA:3.40.50.300 G3DSA:3.40.50.300[251-506]T 1.10000150671643E-48 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19222 [6-306]T 0.0 PTHR19222 PTHR19222 PTHR19222
PTHR19222:SF12 [6-306]T 0.0 PTHR19222:SF12 PTHR19222:SF12 PTHR19222:SF12
SSF52540 [2-232]T 9.4E-60 SSF52540 SSF52540[252-493]T 4.1E-45 SSF52540 SSF52540 SSF52540


COGS Summary:  COGS Search
BeTs to 8 clades of COG1129
COG name: ABC-type sugar (aldose) transport system, ATPase component
Functional Class: G
The phylogenetic pattern of COG1129 is a--k--V-EB-H--gpOL---
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5.3e-25.
    IPB001140A    20-66
    IPB001140B    139-177
    IPB001140C    194-223


 ProDom Summary:  Protein Domain Search
Residues 334-392 are 72% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE SUGAR) protein domain (PD003603 which is seen in Q9CFY3_LACLA.

Residues 80-133 are 64% similar to a (PROTEOME COMPLETE ATP-BINDING TRANSPORT) protein domain (PD404313 which is seen in O05253_BACSU.

Residues 74-181 are 27% similar to a (ATP-BINDING PROTEOME COMPLETE LONG) protein domain (PD292101 which is seen in Q9YG38_AERPE.

Residues 449-483 are 62% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079 which is seen in O59404_PYRHO.

Residues 74-139 are 54% similar to a (ATP-BINDING TRANSPORT SUGAR MEMBRANE) protein domain (PD416141 which is seen in Q9WXV8_THEMA.

Residues 74-141 are 72% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD350414 which is seen in Q9CFY3_LACLA.

Residues 404-446 are 72% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD022456 which is seen in Q9WXV8_THEMA.

Residues 74-219 are 24% similar to a (ATP-BINDING PROTEOME RIBOSE/GALACTOSE) protein domain (PD215671 which is seen in O83322_TREPA.

Residues 73-138 are 46% similar to a (ATP-BINDING TRANSPORT MGLA COMPLETE) protein domain (PD331438 which is seen in Q9X776_MYCAA.

Residues 449-498 are 90% similar to a (ATP-BINDING PROTEOME TRANSPORT COMPLETE) protein domain (PD416084 which is seen in Q9CFY3_LACLA.

Residues 185-225 are 82% similar to a (ATP-BINDING TRANSPORT PROTEOME SUGAR COMPLETE) protein domain (PD404861 which is seen in Q9CFY3_LACLA.

Residues 446-484 are 61% similar to a (ATP-BINDING PROTEOME MGLA) protein domain (PD383394 which is seen in O51620_BORBU.

Residues 449-500 are 50% similar to a (ATP-BINDING PROTEOME COMPLETE SUGAR) protein domain (PD384098 which is seen in Q9RVR5_DEIRA.

Residues 336-445 are 33% similar to a (ATP-BINDING PROTEOME 498AA SYSTEM) protein domain (PD396384 which is seen in Q9Y8P5_AERPE.

Residues 71-136 are 44% similar to a (ATPASE) protein domain (PD389663 which is seen in O06761_MYCFE.

Residues 22-66 are 71% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in Q9CFY3_LACLA.

Residues 404-445 are 90% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9CFY3_LACLA.

Residues 76-135 are 43% similar to a (ATP-BINDING TRANSPORT SUGAR PROTEOME) protein domain (PD002402 which is seen in Q9K7C3_BACHD.


Paralogs:  Local Blast Search
SMu1023 is paralogously related (blast p-value < 1e-3) to SMu1380, SMu0418, SMu1518, SMu0517, SMu1920, SMu1003, SMu0731, SMu0390, SMu0849, SMu1751, SMu0218, SMu0976, SMu1079, SMu1649, SMu1757, SMu1762, SMu0596, SMu1517, SMu0916, SMu1093, SMu1949, SMu1288, SMu1001, SMu1316, SMu0786, SMu1068, SMu1246, SMu1231, SMu0944, SMu0971, SMu0884, SMu0374, SMu1210, SMu1950, SMu0805, SMu0594, SMu0335, SMu1428, SMu0825, SMu1064, SMu0950, SMu1410, SMu0666, SMu0216, SMu0837, SMu0476, SMu0907, SMu1065, SMu0234, SMu1811, SMu1710, SMu0258, SMu0235, SMu0164, SMu1545, SMu0986, SMu1050, SMu0824, SMu1959, SMu0823, SMu0752, SMu0836, SMu1306, SMu0224, SMu0475, SMu1036, SMu1037, SMu1724, SMu0987, SMu0024, SMu1202, SMu0729, and SMu1686, all with ATP binding capabilities.


Pfam Summary:  Pfam Search
Residues 31 to 217 (E-value = 3.8e-50) place SMu1023 in the ABC_tran family which is described as ABC transporter (PF00005)
Residues 284 to 478 (E-value = 3.2e-15) place SMu1023 in the ABC_tran family which is described as ABC transporter (PF00005)

 Top PDB Hits:
pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 109 6e-025
pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 92 2e-019

Gene Protein Sequence:
MAQHVIEMREITKKFDDFVANDHINLDLRKGEIHALLGENGAGKSTLMNM
LAGLLEPTSGSIKINGSAVTIDSPSKSAQLGIGMVHQHFMLVEAFTVTEN
IILGNEVVKNGILDLKKAGQEIKALSEKYGLAVDPNAKIADISVGAQQRV
EILKTLYRGADILIFDEPTAVLTPSEIQELMTIMKSLVKEGKSIILITHK
LDEIRSVADRVTVIRRGKSIETVEVSGTTSQDLAEMMVGRSVSFTIEKTP
TKPKETILSIKDLVVNENRGIPAIKGLSLEVKAGEIIGIAGIDGNGQSEL
VQAITGLRKIKSGHLTIKGQDVTKLSTRKITELSVGHVPEDRHRDGLILE
LTMAENLALQTYYKAPLSHNGVLNYSKINEHGRHLMQEFDVRGANELIPA
KGFSGGNQQKAIIAREVDRDPDLLIVSQPTRGLDVGAIEYIHKRLIAERD
EGKAVLLVSFELDEILNLSDRIAVIHDGQIQGIVTPETTNKQELGILMAG
GSIEREEINV

Gene Nucleotide Sequence:  Sequence Viewer
ATGGCGCAACATGTCATTGAAATGAGAGAGATTACTAAAAAATTTGATGA
TTTTGTGGCTAATGATCACATCAATCTTGATCTCAGAAAAGGTGAGATTC
ATGCTTTGCTTGGTGAAAATGGAGCAGGGAAGTCAACTTTGATGAATATG
CTTGCAGGTTTGCTTGAACCTACTAGTGGTAGCATTAAGATTAATGGTTC
GGCTGTTACGATTGATTCGCCCTCTAAGTCAGCTCAATTAGGTATCGGGA
TGGTTCACCAACATTTTATGTTAGTTGAAGCATTTACGGTTACTGAAAAT
ATCATTTTGGGAAATGAAGTTGTCAAAAATGGTATATTAGATCTTAAAAA
AGCTGGCCAAGAAATTAAAGCACTTTCTGAAAAGTATGGTTTAGCTGTAG
ATCCCAATGCTAAGATTGCTGATATTTCTGTCGGTGCTCAGCAACGTGTT
GAAATTCTTAAAACACTTTATCGTGGTGCTGATATTTTAATTTTTGATGA
ACCAACAGCTGTTTTGACACCTTCTGAAATTCAGGAATTGATGACTATCA
TGAAGAGTCTTGTCAAAGAAGGCAAATCTATTATTTTGATTACTCATAAG
TTGGATGAAATTAGGTCAGTAGCTGATCGTGTTACTGTAATTCGTCGCGG
TAAGAGTATTGAGACAGTTGAGGTCTCTGGCACCACTTCACAGGATTTAG
CTGAGATGATGGTTGGGCGTTCTGTTTCATTTACAATAGAAAAAACGCCA
ACAAAACCTAAAGAAACCATTTTGTCTATCAAAGATCTTGTAGTCAATGA
AAATAGAGGAATTCCTGCTATTAAAGGTTTGTCTTTAGAGGTTAAGGCTG
GTGAAATTATCGGTATTGCTGGTATTGATGGCAATGGGCAAAGTGAATTA
GTTCAAGCTATCACAGGATTACGTAAGATAAAATCTGGTCATTTAACAAT
CAAAGGACAAGATGTGACCAAACTTTCGACCCGTAAGATTACAGAGCTCA
GTGTTGGTCATGTTCCTGAAGACCGTCATCGTGATGGTCTGATTCTTGAG
TTAACTATGGCAGAAAACCTCGCTCTTCAAACATATTATAAGGCCCCCCT
AAGTCACAATGGTGTTTTGAATTATAGTAAAATCAATGAACATGGTCGTC
ACTTAATGCAGGAATTTGATGTTCGCGGAGCTAATGAACTTATTCCAGCC
AAAGGATTTTCAGGCGGCAATCAGCAAAAAGCTATCATTGCTCGTGAGGT
TGACCGTGATCCAGACTTATTAATTGTTAGTCAGCCGACACGAGGTCTTG
ATGTTGGAGCTATTGAATATATTCATAAACGTTTAATTGCAGAGCGTGAT
GAAGGCAAGGCTGTTCTATTAGTCAGTTTTGAACTTGATGAAATTCTCAA
CCTGTCAGATCGTATTGCTGTTATTCATGATGGTCAAATCCAAGGTATTG
TTACACCAGAAACAACTAATAAACAAGAACTAGGAATTTTAATGGCTGGT
GGCAGTATTGAAAGGGAGGAAATAAATGTCTAA

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